RPS6KC1

RPS6KC1
Identifiers
Aliases	RPS6KC1, RPK118, RSKL1, S6K-delta-1, S6PKh1, humS6PKh1, ribosomal protein S6 kinase C1
External IDs	OMIM: 617517; MGI: 2443419; GeneCards: RPS6KC1
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	190,643,967 bp
RNA expression pattern
	n/a
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; supraoptic nucleus; ; granulocyte; ; neural layer of retina; ; muscle of thigh; ; stroma of bone marrow; ; otic vesicle; ; cingulate gyrus; ; saccule; ; yolk sac;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; phosphatidylinositol binding; kinase activity; lipid binding;
Cellular component	membrane; cytoplasm; endosome; early endosome;
Biological process	protein phosphorylation; signal transduction; phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	26750
	320119
	ENSG00000136643
	ENSMUSG00000089872
	Q96S38
	Q8BLK9
NM_001136138; NM_001287218; NM_001287219; NM_001287220; NM_001287221;
	NM_012424
	NM_178775
NP_001129610; NP_001274147; NP_001274148; NP_001274149; NP_001274150;
	NP_036556; NP_001336575; NP_001336576; NP_001336577; NP_001336578; NP_001336579; NP_001336580; NP_001336581; NP_001336582; NP_001336583; NP_001336586; NP_001336587; NP_001336588; NP_001336589; NP_001336590; NP_001336591; NP_001336592; NP_001336593; NP_001336594; NP_001336595; NP_001336596; NP_001336597; NP_001336598; NP_001336599; NP_001336600; NP_001336601
	NP_848890
	Wikidata
View/Edit Human	View/Edit Mouse

Ribosomal protein S6 kinase delta-1 is an enzyme that in humans is encoded by the RPS6KC1 gene.

References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000089872 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zhang H, Yu L, Mao N, Fu Q, Tu Q, Gao J, Zhao S (Feb 2000). "Cloning, characterization, and chromosome mapping of RPS6KC1, a novel putative member of the ribosome protein S6 kinase family, to chromosome 12q12-q13.1". Genomics. 61 (3): 314–8. doi:10.1006/geno.1999.5963. PMID 10552933.
↑ "Entrez Gene: RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1".

Hayashi S, Okada T, Igarashi N, Fujita T, Jahangeer S, Nakamura S (2002). "Identification and characterization of RPK118, a novel sphingosine kinase-1-binding protein". J. Biol. Chem. 277 (36): 33319–24. doi:10.1074/jbc.M201442200. hdl:20.500.14094/D1002671. PMID 12077123.
Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lehner B, Semple JI, Brown SE, Counsell D, Campbell R, Sanderson CM (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Liu L, Yang C, Yuan J, Chen X, Xu J, Wei Y, Yang J, Lin G, Yu L (2005). "RPK118, a PX domain-containing protein, interacts with peroxiredoxin-3 through pseudo-kinase domains". Mol. Cells. 19 (1): 39–45. doi:10.1016/S1016-8478(23)13134-7. PMID 15750338.
Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000089872 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10552933-4] Zhang H, Yu L, Mao N, Fu Q, Tu Q, Gao J, Zhao S (Feb 2000). "Cloning, characterization, and chromosome mapping of RPS6KC1, a novel putative member of the ribosome protein S6 kinase family, to chromosome 12q12-q13.1". Genomics. 61 (3): 314–8. doi:10.1006/geno.1999.5963. PMID 10552933.

[entrez-5] "Entrez Gene: RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1".

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

RPS6KC1

References

Further reading