Cefaloglycin

Cefaloglycin
Clinical data
Trade names	Kafocin
License data	US FDA: Withdrawn;
ATC code	none;
Identifiers
	IUPAC name (6R,7R)-3-[(acetyloxy)methyl]-7-{[(2R)-2-amino-2-phenylacetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;
CAS Number	3577-01-3 ;
PubChem CID	19150;
DrugBank	DB00689 ;
ChemSpider	18069 ;
UNII	HD2D469W6U;
KEGG	D01949 ;
ChEBI	CHEBI:34613 ;
ChEMBL	ChEMBL1200971 ;
CompTox Dashboard (EPA)	DTXSID4022781 ;
ECHA InfoCard	100.020.633
Chemical and physical data
Formula	C18H19N3O6S
Molar mass	405.43 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)[C@@H](c3ccccc3)N)COC(=O)C)C(=O)O;
	InChI InChI=1S/C18H19N3O6S/c1-9(22)27-7-11-8-28-17-13(16(24)21(17)14(11)18(25)26)20-15(23)12(19)10-5-3-2-4-6-10/h2-6,12-13,17H,7-8,19H2,1H3,(H,20,23)(H,25,26)/t12-,13-,17-/m1/s1 ; Key:FUBBGQLTSCSAON-PBFPGSCMSA-N ;
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Cefaloglycin INN (also spelled cephaloglycin) was the first cephalosporin antibiotic to be suitable for oral administration. It was sold in the United States by Eli Lilly and Company as Kafocin. It was discontinued by its manufacturer, and as of 2026, no generic versions have been approved.

References

↑ "Cephaloglycin". Inxight Drugs. National Center for Advancing Translational Sciences (NCATS), National Institutes of Health. Retrieved August 4, 2026.
↑ PubChem. "Cephaloglycin". pubchem.ncbi.nlm.nih.gov. Retrieved 2026-08-04.
↑ "Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book): Kafocin (NDA 050219)". U.S. Food and Drug Administration. Retrieved 4 August 2026.

External links

Media related to Cefaloglycin at Wikimedia Commons

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[1] "Cephaloglycin". Inxight Drugs. National Center for Advancing Translational Sciences (NCATS), National Institutes of Health. Retrieved August 4, 2026.

[2] PubChem. "Cephaloglycin". pubchem.ncbi.nlm.nih.gov. Retrieved 2026-08-04.

[3] "Approved Drug Products with Therapeutic Equivalence Evaluations (Orange Book): Kafocin (NDA 050219)". U.S. Food and Drug Administration. Retrieved 4 August 2026.