EIF5

EIF5
Identifiers
Aliases	EIF5, EIF-5, EIF-5A, eukaryotic translation initiation factor 5, Eukaryotic initiation factor 5
External IDs	OMIM: 601710; MGI: 95309; GeneCards: EIF5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E9H, 2G2K, 2IU1
Gene location (Human)
Chr.	Chromosome 14 (human)
End	103,345,025 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	111,513,186 bp
RNA expression pattern
	Top expressed in
	postcentral gyrus; ; pons; ; sperm; ; external globus pallidus; ; lateral nuclear group of thalamus; ; superior frontal gyrus; ; pars compacta; ; inferior olivary nucleus; ; superior vestibular nucleus; ; oocyte;
	Top expressed in
	otic placode; ; medullary collecting duct; ; renal corpuscle; ; saccule; ; otic vesicle; ; blood; ; human fetus; ; lacrimal gland; ; tail of embryo; ; spermatocyte;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	translation initiation factor activity; nucleotide binding; translation factor activity, RNA binding; GTP binding; GTPase activity; protein binding; eukaryotic initiation factor eIF2 binding; RNA binding; cadherin binding; GDP-dissociation inhibitor activity;
Cellular component	nucleus; plasma membrane; cytoplasm; cytosol;
Biological process	regulation of translational initiation; protein biosynthesis; activation of GTPase activity; formation of translation preinitiation complex; translational initiation; formation of cytoplasmic translation initiation complex;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	1983
	217869
	ENSG00000100664
	ENSMUSG00000021282
	P55010
	P59325
	NM_183004; NM_001969
	NM_173363; NM_178041
	NP_001960; NP_892116
	NP_775539; NP_829887
	Wikidata
View/Edit Human	View/Edit Mouse

Eukaryotic translation initiation factor 5 is a protein that in humans is encoded by the EIF5 gene.

EIF5 is a GTPase-activating protein.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100664 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021282 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Si K, Das K, Maitra U (Aug 1996). "Characterization of multiple mRNAs that encode mammalian translation initiation factor 5 (eIF-5)". J Biol Chem. 271 (28): 16934–8. doi:10.1074/jbc.271.28.16934. PMID 8663286.
↑ "Entrez Gene: EIF5 eukaryotic translation initiation factor 5".
↑ Das S, Ghosh R, Maitra U (March 2001). "Eukaryotic translation initiation factor 5 functions as a GTPase-activating protein". J. Biol. Chem. 276 (9): 6720–6. doi:10.1074/jbc.M008863200. PMID 11092890.

External links

Cap-dependent translation initiation from Nature Reviews Microbiology. A good image and overview of the function of initiation factors
PDBe-KB provides an overview of all the structure information available in the PDB for Human Eukaryotic translation initiation factor 5 (EIF5)