Echinopsidine

Echinopsidine
Skeletal formula of echinopsidine
Clinical data
Other namesEchinopsidine Iodide
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 1-Methyl-2,3-dihydroquinolin-4-imine
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC10H12N2
Molar mass160.220 g·mol−1

Echinopsidine (Adepren) is an antidepressant that was under development in Bulgaria for the treatment of depression. It increases serotonin, norepinephrine, and dopamine levels in the brain and is believed to act as a monoamine oxidase inhibitor (MAOI). Echinopsidine is found naturally in Echinops echinatus along with the related alkaloids echinopsine and echinozolinone.

See also

References

  1. ↑ Guliamov MG (1982). "[Experience with the use of new Bulgarian psychotropic drugs]". Zhurnal Nevropatologii I Psikhiatrii imeni S.S. Korsakova (in Russian). 82 (11): 115–122. PMID 6758442.
  2. ↑ Guliamov MG (1986). "[Comparative evaluation of the therapeutic efficacy of the antidepressants adepren, linamiphen and emovit]". Zhurnal Nevropatologii I Psikhiatrii imeni S.S. Korsakova (in Russian). 86 (4): 582–587. PMID 3716711.
  3. ↑ Tiutiulkova N, Gorancheva I (1978). "[Effect of adepren on the cerebral concentration of serotonin]". Eksperimentalna Meditsina I Morfologiia (in Bulgarian). 17 (2): 83–85. PMID 658004.
  4. ↑ Stefanova D, Tiutiulkova N, Nikolova M (1976). "[Effect of adepren on the behavior and brain catecholamines of rats in an open field setup]". Eksperimentalna Meditsina I Morfologiia (in Bulgarian). 15 (1): 42–46. PMID 1269462.
  5. ↑ Tiutiulkova NI, Gorancheva I (1975). "[Excretion of dopamine, noradrenaline, adrenaline, vanilmandelic acid and 5-hydroxyindoleacetic acid in the urine of volunteers treated with adepren]". Eksperimentalna Meditsina I Morfologiia (in Bulgarian). 14 (4): 187–189. PMID 1222713.
  6. ↑ Khare CP (2007). "Echinops echinatus Roxb.". Indian Medicinal Plants An Illustrated Dictionary. Springer-Verlag Berlin Heidelberg. ISBN 978-0-387-70637-5.