Interleukin 11 receptor alpha subunit

IL11RA
Identifiers
AliasesIL11RA, CRSDA, Interleukin 11 receptor alpha subunit, interleukin 11 receptor subunit alpha
External IDsOMIM: 600939; MGI: 109123; GeneCards: IL11RA
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

3590

16158

Ensembl

ENSG00000137070

ENSMUSG00000078735

UniProt

Q14626

P70225

RefSeq (mRNA)

NM_001142784
NM_004512
NM_147162

NM_010550

RefSeq (protein)

NP_001136256

NP_001092818
NP_001365603

Location (UCSC)Chr 9: 34.65 – 34.66 MbChr 4: 42.66 – 42.67 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin 11 receptor, alpha subunit is a subunit of the interleukin 11 receptor. IL11RA is its human gene.

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Alternative splicing has been observed at this locus and two variants, each encoding a distinct isoform, have been identified.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000137070 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000078735 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: IL11RA interleukin 11 receptor, alpha".

Further reading