IST1 homolog

IST1
Identifiers
Aliases	IST1, OLC1, KIAA0174, ESCRT-III associated factor, CHMP8, IST1 factor associated with ESCRT-III
External IDs	OMIM: 616434; MGI: 1919205; GeneCards: IST1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3FRR, 3FRS, 4U7E, 4U7I, 4U7Y, 4WZX, 3JC1
Gene location (Human)
Chr.	Chromosome 16 (human)
End	71,931,199 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	110,419,892 bp
RNA expression pattern
	Top expressed in
	left ovary; ; gastric mucosa; ; rectum; ; right ovary; ; right uterine tube; ; skin of leg; ; body of uterus; ; skin of abdomen; ; canal of the cervix; ; anterior pituitary;
	Top expressed in
	transitional epithelium of urinary bladder; ; medullary collecting duct; ; vestibular sensory epithelium; ; stroma of bone marrow; ; superior cervical ganglion; ; hair follicle; ; renal corpuscle; ; pyloric antrum; ; gastric mucosa; ; dermis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; protein-containing complex binding; protein binding; MIT domain binding; cadherin binding;
Cellular component	cytoplasm; cytosol; centrosome; Flemming body; microtubule organizing center; extracellular exosome; cytoskeleton; cytoplasmic vesicle; endoplasmic reticulum-Golgi intermediate compartment; midbody; nuclear envelope; nucleus; extracellular region; azurophil granule lumen; intracellular membrane-bounded organelle; chromatin;
Biological process	protein localization; viral release from host cell; abscission; establishment of protein localization; viral capsid secondary envelopment; multivesicular body assembly; cytokinesis; positive regulation of collateral sprouting; cell division; positive regulation of proteolysis; protein transport; cell cycle; ESCRT III complex disassembly; neutrophil degranulation; cytoskeleton-dependent cytokinesis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9798
	71955
	ENSG00000182149
	ENSMUSG00000031729
	P53990
	Q9CX00
NM_014761; NM_001270975; NM_001270976; NM_001270977; NM_001270978;
	NM_001270979
	NM_028018; NM_001361562
NP_001257904; NP_001257905; NP_001257906; NP_001257907; NP_001257908;
	NP_055576
	NP_082294; NP_001348491
	Wikidata
View/Edit Human	View/Edit Mouse

IST1 homolog is a protein that in humans is encoded by the IST1 gene (previously KIAA0174). IST1 homolog interacts with the ESCRT (endosomal sorting complexes required for transport), which is involved with vesicle budding and cytokinesis.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000182149 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031729 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
1 2 "IST1 IST1 factor associated with ESCRT-III [ Homo sapiens (human)". ncbi.nlm.nih.gov. 2026-07-23. Retrieved 2026-08-03.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human IST1 homolog

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000182149 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031729 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8724849-5] Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (Nov 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.

[entrez-6] 1 2 "IST1 IST1 factor associated with ESCRT-III [ Homo sapiens (human)". ncbi.nlm.nih.gov. 2026-07-23. Retrieved 2026-08-03.

IST1 homolog

References

Further reading

External links