KIF4A

KIF4A
Identifiers
Aliases	KIF4A, KIF4, KIF4G1, MRX100, kinesin family member 4A, XLID100
External IDs	OMIM: 300521; MGI: 108389; GeneCards: KIF4A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3ZFC, 6OYL, 3ZFD
Gene location (Human)
Chr.	X chromosome (human)
End	70,420,886 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	99,770,820 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; ventricular zone; ; ganglionic eminence; ; gonad; ; testicle; ; bone marrow; ; trabecular bone; ; stromal cell of endometrium; ; mucosa of transverse colon;
	Top expressed in
	zygote; ; primary oocyte; ; otic placode; ; genital tubercle; ; otic vesicle; ; secondary oocyte; ; tail of embryo; ; saccule; ; ventricular zone; ; fetal liver hematopoietic progenitor cell;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; microtubule motor activity; nucleotide binding; microtubule binding; protein binding; ATP binding; plus-end-directed microtubule motor activity; ATPase activity;
Cellular component	cytosol; membrane; kinesin complex; nuclear matrix; spindle; nucleoplasm; chromosome; spindle microtubule; microtubule; cytoskeleton; nucleus; axon cytoplasm; midbody; cytoplasm; intercellular bridge;
Biological process	antigen processing and presentation of exogenous peptide antigen via MHC class II; mitotic spindle midzone assembly; mitotic cytokinesis; organelle organization; anterograde axonal transport; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; microtubule-based movement; mitotic spindle organization;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	24137
	16571
	ENSG00000090889
	ENSMUSG00000034311
	O95239
	P33174
	NM_012310
	NM_008446
	NP_036442
	NP_032472
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin family member 4A is a protein that in humans is encoded by the KIF4A gene.

Function

Kinesins, such as KIF4A, are microtubule-based motor proteins that generate directional movement along microtubules. They are involved in many crucial cellular processes, including cell division.

Interactions

KIF4A has been shown to interact with HMG20B and DNMT3B.

Clinical significance

NTCP is the entry receptor for both Hepatitis B (HBV) and Hepatitis D viruses (HDV). KIF4 was found to play an essential role in HBV and HDV infection through its regulation of the retrograde transport of NTCP from the cytoplasm to the cell surface where it acts as a receptor for HBV/HDV infection.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000090889 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034311 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ha MJ, Yoon J, Moon E, Lee YM, Kim HJ, Kim W (Jun 2000). "Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization". Cytogenetics and Cell Genetics. 88 (1–2): 41–42. doi:10.1159/000015482. PMID 10773663. S2CID 46074226.
1 2 "Entrez Gene: KIF4A kinesin family member 4A".
↑ Lee YM, Kim W (September 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". The Biochemical Journal. 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC 1223617. PMID 12809554.
↑ Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, et al. (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Research. 32 (9): 2716–2729. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.
↑ Yan H, Zhong G, Xu G, He W, Jing Z, Gao Z, et al. (November 2012). Chen ZJ (ed.). "Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus". eLife. 1 e00049. doi:10.7554/eLife.00049. PMC 3485615. PMID 23150796.
↑ Gad SA, Sugiyama M, Tsuge M, Wakae K, Fukano K, Oshima M, et al. (March 2022). "The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro". PLOS Pathogens. 18 (3) e1009983. doi:10.1371/journal.ppat.1009983. PMC 8970526. PMID 35312737.

External links

"KIF4A Foundation".

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000090889 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034311 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10773663-5] Ha MJ, Yoon J, Moon E, Lee YM, Kim HJ, Kim W (Jun 2000). "Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization". Cytogenetics and Cell Genetics. 88 (1–2): 41–42. doi:10.1159/000015482. PMID 10773663. S2CID 46074226.

[entrez-6] 1 2 "Entrez Gene: KIF4A kinesin family member 4A".

[pmid12809554-7] Lee YM, Kim W (September 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". The Biochemical Journal. 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC 1223617. PMID 12809554.

[pmid15148359-8] Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, et al. (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Research. 32 (9): 2716–2729. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.

[9] Yan H, Zhong G, Xu G, He W, Jing Z, Gao Z, et al. (November 2012). Chen ZJ (ed.). "Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus". eLife. 1 e00049. doi:10.7554/eLife.00049. PMC 3485615. PMID 23150796.

[10] Gad SA, Sugiyama M, Tsuge M, Wakae K, Fukano K, Oshima M, et al. (March 2022). "The kinesin KIF4 mediates HBV/HDV entry through the regulation of surface NTCP localization and can be targeted by RXR agonists in vitro". PLOS Pathogens. 18 (3) e1009983. doi:10.1371/journal.ppat.1009983. PMC 8970526. PMID 35312737.