KIF2A
Kinesin-like protein KIF2A is a protein that in humans is encoded by the KIF2A gene. In mice, KIF2A is essential for proper neurogenesis and deficiency of KIF2A in mature neurons results in the loss of those neurons.
Kinesins, such as KIF2, are microtubule-associated motor proteins. For background information on kinesins, see MIM 148760.[supplied by OMIM]
References
- 1 2 3 GRCh38: Ensembl release 89: ENSG00000068796 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021693 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ Debernardi S, Fontanella E, De Gregorio L, Pierotti MA, Delia D (May 1997). "Identification of a novel human kinesin-related gene (HK2) by the cDNA differential display technique". Genomics. 42 (1): 67–73. doi:10.1006/geno.1997.4720. PMID 9177777.
- 1 2 "Entrez Gene: KIF2A kinesin heavy chain member 2A".
- ↑ Ruiz-Reig N, Chehade G, Hakanen J, Aittaleb M, Wierda K, De Wit J, et al. (November 2022). "KIF2A deficiency causes early-onset neurodegeneration". Proceedings of the National Academy of Sciences of the United States of America. 119 (46) e2209714119. Bibcode:2022PNAS..11909714R. doi:10.1073/pnas.2209714119. PMC 9674219. PMID 36343267.
Further reading
- Manning AL, Ganem NJ, Bakhoum SF, Wagenbach M, Wordeman L, Compton DA (August 2007). "The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells". Molecular Biology of the Cell. 18 (8): 2970–2979. doi:10.1091/mbc.E07-02-0110. PMC 1949365. PMID 17538014.
- Schepis A, Stauber T, Krijnse Locker J (August 2007). "Kinesin-1 plays multiple roles during the vaccinia virus life cycle". Cellular Microbiology. 9 (8): 1960–1973. doi:10.1111/j.1462-5822.2007.00927.x. PMID 17394562. S2CID 23205204.
- Li C, Zheng Y, Qin W, Tao R, Pan Y, Xu Y, et al. (October 2006). "A family-based association study of kinesin heavy chain member 2 gene (KIF2) and schizophrenia". Neuroscience Letters. 407 (2): 151–155. doi:10.1016/j.neulet.2006.08.025. PMID 16959419. S2CID 32742823.
- Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (April 2006). "Phosphoproteome analysis of the human mitotic spindle". Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391–5396. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
- Ganem NJ, Upton K, Compton DA (October 2005). "Efficient mitosis in human cells lacking poleward microtubule flux". Current Biology. 15 (20): 1827–1832. Bibcode:2005CBio...15.1827G. doi:10.1016/j.cub.2005.08.065. PMID 16243029. S2CID 8541946.
- Ganem NJ, Compton DA (August 2004). "The KinI kinesin Kif2a is required for bipolar spindle assembly through a functional relationship with MCAK". The Journal of Cell Biology. 166 (4): 473–478. doi:10.1083/jcb.200404012. PMC 2172212. PMID 15302853.
- Johnson JM, Castle J, Garrett-Engele P, Kan Z, Loerch PM, Armour CD, et al. (December 2003). "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays". Science. 302 (5653): 2141–2144. Bibcode:2003Sci...302.2141J. doi:10.1126/science.1090100. PMID 14684825. S2CID 10007258.
External links
- Overview of all the structural information available in the PDB for UniProt: O00139 (Human Kinesin-like protein KIF2A) at the PDBe-KB.
PDB gallery | |
|---|---|
|
 | This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by adding missing information. |