Mitochondrial ribosomal protein L19

MRPL19
Identifiers
Aliases	MRPL19, L19mt, MRP-L15, MRP-L19, MRPL15, RLX1, RPML15, mitochondrial ribosomal protein L19
External IDs	OMIM: 611832; MGI: 1926274; GeneCards: MRPL19
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J7Y, 3J9M
Gene location (Human)
Chr.	Chromosome 2 (human)
End	75,690,851 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	81,942,939 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; right adrenal gland; ; Skeletal muscle tissue of biceps brachii; ; left adrenal gland; ; rectum; ; right adrenal cortex; ; gingival epithelium; ; left adrenal cortex; ; islet of Langerhans; ; muscle of thigh;
	Top expressed in
	endocardial cushion; ; medullary collecting duct; ; epiblast; ; otic placode; ; migratory enteric neural crest cell; ; blastocyst; ; atrioventricular valve; ; atrium; ; renal corpuscle; ; lateral septal nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of ribosome;
Cellular component	mitochondrial inner membrane; ribosome; nuclear membrane; intracellular anatomical structure; nucleus; mitochondrion; mitochondrial large ribosomal subunit;
Biological process	mitochondrial translational elongation; mitochondrial translational termination; protein biosynthesis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9801
	56284
	ENSG00000115364
	ENSMUSG00000030045
	P49406
	Q9D338
	NM_014763
	NM_026490
	NP_055578
	NP_080766
	Wikidata
View/Edit Human	View/Edit Mouse

39S ribosomal protein L19, mitochondrial is a protein that in humans is encoded by the MRPL19 gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115364 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030045 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kenmochi N, Suzuki T, Uechi T, Magoori M, Kuniba M, Higa S, et al. (Sep 2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
↑ Anthoni H, Zucchelli M, Matsson H, Muller-Myhsok B, Fransson I, Schumacher J, et al. (Apr 2007). "A locus on 2p12 containing the co-regulated MRPL19 and C2ORF3 genes is associated to dyslexia". Human Molecular Genetics. 16 (6): 667–677. doi:10.1093/hmg/ddm009. PMID 17309879.
1 2 "Entrez Gene: MRPL19 mitochondrial ribosomal protein L19".

Nagase T, Miyajima N, Tanaka A, Sazuka T, Seki N, Sato S, et al. (1995). "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 2 (1): 37–43. doi:10.1093/dnares/2.1.37. PMID 7788527.
The Sanger Centre, The Washington University Genome Sequencing Center (Nov 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Graack HR, Bryant ML, O'Brien TW (Dec 1999). "Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle". Biochemistry. 38 (50): 16569–16577. doi:10.1021/bi991543s. PMID 10600119.
Hoja MR, Wahlestedt C, Höög C (Aug 2000). "A visual intracellular classification strategy for uncharacterized human proteins". Experimental Cell Research. 259 (1): 239–246. doi:10.1006/excr.2000.4948. PMID 10942595.
Suzuki T, Terasaki M, Takemoto-Hori C, Hanada T, Ueda T, Wada A, et al. (Jun 2001). "Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria". Journal of Biological Chemistry. 276 (24): 21724–21736. doi:10.1074/jbc.M100432200. PMID 11279069.
Zhang Z, Gerstein M (May 2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–480. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.