Mitochondrial ribosomal protein L37

MRPL37
Identifiers
Aliases	MRPL37, L37mt, MRP-L2, MRP-L37, MRPL2, RPML2, mitochondrial ribosomal protein L37, L2mt
External IDs	OMIM: 611843; MGI: 1926268; GeneCards: MRPL37
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J7Y, 3J9M
Gene location (Human)
Chr.	Chromosome 1 (human)
End	54,225,464 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	106,924,065 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; muscle of thigh; ; right adrenal gland; ; skin of arm; ; right adrenal cortex; ; tibialis anterior muscle; ; left ventricle; ; right lobe of liver; ; left adrenal gland; ; apex of heart;
	Top expressed in
	genital tubercle; ; tail of embryo; ; muscle of thigh; ; right kidney; ; ventricular zone; ; embryo; ; lip; ; skeletal muscle tissue; ; embryo; ; triceps brachii muscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of ribosome; RNA binding;
Cellular component	mitochondrial inner membrane; ribosome; mitochondrial ribosome; mitochondrial large ribosomal subunit; mitochondrion;
Biological process	mitochondrial translational elongation; mitochondrial translational termination; protein biosynthesis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51253
	56280
	ENSG00000116221
	ENSMUSG00000028622
	Q9BZE1
	Q921S7
	NM_016491; NM_001330602
	NM_025500
	NP_001317531; NP_057575
	NP_079776
	Wikidata
View/Edit Human	View/Edit Mouse

39S ribosomal protein L37, mitochondrial is a protein that in humans is encoded by the MRPL37 gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000116221 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028622 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Graack HR, Bryant ML, O'Brien TW (Jan 2000). "Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle". Biochemistry. 38 (50): 16569–77. doi:10.1021/bi991543s. PMID 10600119.
1 2 "Entrez Gene: MRPL37 mitochondrial ribosomal protein L37".

External links

Overview of all the structural information available in the PDB for UniProt: Q9BZE1 (39S ribosomal protein L37, mitochondrial) at the PDBe-KB.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

This Ribosomal protein–related article is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000116221 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028622 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10600119-5] Graack HR, Bryant ML, O'Brien TW (Jan 2000). "Identification of mammalian mitochondrial ribosomal proteins (MRPs) by N-terminal sequencing of purified bovine MRPs and comparison to data bank sequences: the large subribosomal particle". Biochemistry. 38 (50): 16569–77. doi:10.1021/bi991543s. PMID 10600119.

[entrez-6] 1 2 "Entrez Gene: MRPL37 mitochondrial ribosomal protein L37".

Mitochondrial ribosomal protein L37

References

Further reading

External links