Mitochondrial ribosomal protein L4

MRPL4
Identifiers
Aliases	MRPL4, CGI-28, L4mt, mitochondrial ribosomal protein L4
External IDs	OMIM: 611823; MGI: 2137210; GeneCards: MRPL4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J7Y, 3J9M,%%s3J7Y, 3J9M
Gene location (Human)
Chr.	Chromosome 19 (human)
End	10,260,055 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	20,920,135 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; mucosa of transverse colon; ; right auricle of heart; ; right adrenal gland; ; left adrenal gland; ; right adrenal cortex; ; right lobe of liver; ; left ventricle; ; left adrenal cortex; ; skin of abdomen;
	Top expressed in
	interventricular septum; ; right kidney; ; myocardium of ventricle; ; right ventricle; ; extensor digitorum longus muscle; ; cardiac muscle tissue of left ventricle; ; brown adipose tissue; ; internal carotid artery; ; adrenal gland; ; external carotid artery;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	structural constituent of ribosome; protein binding; RNA binding;
Cellular component	mitochondrial inner membrane; ribosome; mitochondrion; cytosolic ribosome; mitochondrial large ribosomal subunit;
Biological process	mitochondrial translational elongation; mitochondrial translational termination; protein biosynthesis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51073
	66163
	ENSG00000105364
	ENSMUSG00000003299
	Q9BYD3
	Q9DCU6
	NM_015956; NM_146387; NM_146388
	NM_023167; NM_001357899
	NP_057040; NP_666499; NP_666500; NP_057040.2; NP_666499.1
	NP_075656; NP_001344828
	Wikidata
View/Edit Human	View/Edit Mouse

39S ribosomal protein L4, mitochondrial is a protein that in humans is encoded by the MRPL4 gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified alternatively spliced variants that encode different protein isoforms.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000105364 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003299 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: MRPL4 mitochondrial ribosomal protein L4".

External links

Overview of all the structural information available in the PDB for UniProt: Q9BYD3 (39S ribosomal protein L4, mitochondrial) at the PDBe-KB.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

This Ribosomal protein–related article is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000105364 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003299 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: MRPL4 mitochondrial ribosomal protein L4".

Mitochondrial ribosomal protein L4

References

Further reading

External links