Mitochondrial ribosomal protein S24

MRPS24
Identifiers
Aliases	MRPS24, MRP-S24, S24mt, bMRP-47, bMRP47, HSPC335, mitochondrial ribosomal protein S24
External IDs	OMIM: 611986; MGI: 1928142; GeneCards: MRPS24
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J9M
Gene location (Human)
Chr.	Chromosome 7 (human)
End	43,869,893 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	5,665,680 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; muscle of thigh; ; apex of heart; ; left ventricle; ; right adrenal gland; ; body of pancreas; ; left adrenal cortex; ; right adrenal cortex; ; right auricle of heart; ; mucosa of transverse colon;
	Top expressed in
	endocardial cushion; ; lacrimal gland; ; medullary collecting duct; ; renal corpuscle; ; atrioventricular valve; ; facial motor nucleus; ; intercostal muscle; ; Paneth cell; ; epithelium of stomach; ; internal carotid artery;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural constituent of ribosome; RNA binding;
Cellular component	mitochondrial inner membrane; ribosome; mitochondrial ribosome; mitochondrion; mitochondrial small ribosomal subunit;
Biological process	mitochondrial translational elongation; mitochondrial translational termination; protein biosynthesis; mitochondrial translation; biological process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	64951
	64660
	ENSG00000062582
	ENSMUSG00000020477
	Q96EL2
	Q9CQV5
	NM_032014
	NM_026080; NM_001362871
	NP_114403
	NP_080356; NP_001349800
	Wikidata
View/Edit Human	View/Edit Mouse

28S ribosomal protein S24, mitochondrial is a protein that in humans is encoded by the MRPS24 gene.

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 11.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000062582 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020477 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Xu L, He GP, Li A, Ro HS (Apr 1994). "Molecular characterization of the mouse ribosomal protein S24 multigene family: a uniquely expressed intron-containing gene with cell-specific expression of three alternatively spliced mRNAs". Nucleic Acids Res. 22 (4): 646–55. doi:10.1093/nar/22.4.646. PMC 307856. PMID 8127713.
↑ Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.
1 2 "Entrez Gene: MRPS24 mitochondrial ribosomal protein S24".

External links

Overview of all the structural information available in the PDB for UniProt: Q96EL2 (28S ribosomal protein S24, mitochondrial) at the PDBe-KB.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

This Ribosomal protein–related article is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000062582 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020477 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8127713-5] Xu L, He GP, Li A, Ro HS (Apr 1994). "Molecular characterization of the mouse ribosomal protein S24 multigene family: a uniquely expressed intron-containing gene with cell-specific expression of three alternatively spliced mRNAs". Nucleic Acids Res. 22 (4): 646–55. doi:10.1093/nar/22.4.646. PMC 307856. PMID 8127713.

[pmid11279123-6] Cavdar Koc E, Burkhart W, Blackburn K, Moseley A, Spremulli LL (May 2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J Biol Chem. 276 (22): 19363–74. doi:10.1074/jbc.M100727200. PMID 11279123.

[entrez-7] 1 2 "Entrez Gene: MRPS24 mitochondrial ribosomal protein S24".

Mitochondrial ribosomal protein S24

References

Further reading

External links