Mitochondrial ribosomal protein S5

MRPS5
Identifiers
Aliases	MRPS5, MRP-S5, S5mt, mitochondrial ribosomal protein S5, 28S ribosomal protein S5, mitochondrial
External IDs	OMIM: 611972; MGI: 1924971; GeneCards: MRPS5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3J9M
Gene location (Human) Chr. Chromosome 2 (human) Band 2q11.1 Start 95,085,369 bp End 95,122,027 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 F1 Start 127,429,142 bp End 127,448,749 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar hemisphere pancreatic epithelial cell tibialis anterior muscle right lobe of liver gastrocnemius muscle renal medulla deltoid muscle Brodmann area 9 hypothalamus right adrenal gland Top expressed in ventricular zone embryo muscle of thigh spermatocyte embryo blastocyst right kidney neural layer of retina dentate gyrus of hippocampal formation granule cell epiblast More reference expression data BioGPS n/a
Gene ontology Molecular function structural constituent of ribosome RNA binding Cellular component mitochondrial inner membrane ribosome mitochondrion cytosolic small ribosomal subunit mitochondrial small ribosomal subunit Biological process mitochondrial translational elongation mitochondrial translational termination protein biosynthesis Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 64969 77721 Ensembl ENSG00000289685 ENSMUSG00000027374 UniProt P82675 Q99N87 RefSeq (mRNA) NM_031902 NM_001321995 NM_001321996 NM_001321997 NM_029963 RefSeq (protein) NP_001308924 NP_001308925 NP_001308926 NP_114108 NP_084239 Location (UCSC) Chr 2: 95.09 – 95.12 Mb Chr 2: 127.43 – 127.45 Mb PubMed search
Wikidata
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28S ribosomal protein S5, mitochondrial, otherwise called uS5m, is a protein that in humans is encoded by the MRPS5 gene.

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q.

References

Further reading

External links

• Overview of all the structural information available in the PDB for UniProt: P82675 (28S ribosomal protein S5, mitochondrial) at the PDBe-KB.

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