Ninein-like protein

NINL
Identifiers
Aliases	NINL, NLP, dJ691N24.1, ninein like
External IDs	OMIM: 609580; MGI: 1925427; GeneCards: NINL
Gene location (Human)
Chr.	Chromosome 20 (human)
End	25,585,531 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	150,881,302 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; ventricular zone; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; left ovary; ; ganglionic eminence; ; right ovary; ; human kidney; ; right adrenal cortex; ; right lobe of thyroid gland;
	Top expressed in
	otic vesicle; ; superior cervical ganglion; ; Gonadal ridge; ; spermatocyte; ; tail of embryo; ; ventricular zone; ; olfactory epithelium; ; spermatid; ; abdominal wall; ; hand;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	calcium ion binding; protein binding; metal ion binding;
Cellular component	cytoplasm; microtubule; microtubule organizing center; cytosol; intercellular bridge; cytoskeleton; centrosome;
Biological process	G2/M transition of mitotic cell cycle; ciliary basal body-plasma membrane docking; regulation of G2/M transition of mitotic cell cycle; microtubule anchoring at centrosome;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	22981
	78177
	ENSG00000101004
	ENSMUSG00000068115
	Q9Y2I6
	Q6ZQ12
	NM_025176; NM_001318226
	NM_207204
	NP_001305155; NP_079452
	NP_997087
	Wikidata
View/Edit Human	View/Edit Mouse

Ninein-like protein is a protein that in humans is encoded by the NINL gene. It is part of the centrosome.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000101004 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000068115 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
↑ "Entrez Gene: RP4-691N24.1 KIAA0980 protein".
↑ Casenghi, Martina (2003). Functional characterization of the novel centrosomal protein Nlp (ninein-like protein) (PDF) (Ph.D thesis).

Wang Y, Zhan Q (2007). "Cell cycle-dependent expression of centrosomal ninein-like protein in human cells is regulated by the anaphase-promoting complex". J. Biol. Chem. 282 (24): 17712–9. doi:10.1074/jbc.M701350200. PMID 17403670.
Casenghi M, Barr FA, Nigg EA (2005). "Phosphorylation of Nlp by Plk1 negatively regulates its dynein-dynactin-dependent targeting to the centrosome". J. Cell Sci. 118 (Pt 21): 5101–8. doi:10.1242/jcs.02622. PMID 16254247. S2CID 23146359.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Casenghi M, Meraldi P, Weinhart U, et al. (2003). "Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation". Dev. Cell. 5 (1): 113–25. doi:10.1016/S1534-5807(03)00193-X. PMID 12852856.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000101004 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000068115 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10231032-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jul 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.

[entrez-6] "Entrez Gene: RP4-691N24.1 KIAA0980 protein".

[7] Casenghi, Martina (2003). Functional characterization of the novel centrosomal protein Nlp (ninein-like protein) (PDF) (Ph.D thesis).

v t e The centrosome and its components
Centrioles	SASS6 CENPJ CNTROB CEP104 Centrins (CETN1, CETN2 and CETN3) SFI1
Pericentriolar material	BBS4 LCK PCM1 PCNT TNKS TNKS2 TUBE1
other proteins	CCP110 CEP55 CEP57 CEP63 CEP68 CEP70 CEP72 CEP76 CEP78 CEP90 CEP97 CEP120 CEP135 CEP152 CEP164 CEP170 CEP192 CEP215 CEP250 CEP350 CNTRL NIN NINL

Ninein-like protein

References

Further reading