Nucleoside-triphosphatase
| nucleoside-triphosphatase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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| Identifiers | |||||||||
| EC no. | 3.6.1.15 | ||||||||
| CAS no. | 9075-51-8 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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Nucleoside-triphosphatase (NTPase) (EC 3.6.1.15) is an enzyme characterised from mammalian liver and pea seedlings that catalyzes a general hydrolysis reaction:
- nucleoside triphosphate + H2O nucleoside diphosphate + phosphate
For example, the enzyme converts adenosine triphosphate to adenosine diphosphate:
The enzyme is also found in the bacterium Aquifex aeolicus, and has been implicated in human cancers.
This enzyme is a hydrolase, one acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is unspecific diphosphate phosphohydrolase. Other names in common use include nucleoside triphosphate phosphohydrolase, nucleoside-5-triphosphate phosphohydrolase, and nucleoside 5-triphosphatase.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code PDB: 2I3B.
