Neuropeptide B

NPB
Identifiers
AliasesNPB, L7, PPL7, PPneuropeptide B
External IDsOMIM: 607996; MGI: 2387153; GeneCards: NPB
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

256933

208990

Ensembl

ENSG00000183979

ENSMUSG00000044034

UniProt

Q8NG41

Q8K4P1

RefSeq (mRNA)

NM_148896

NM_153288
NM_001347616
NM_001347617

RefSeq (protein)

NP_683694

NP_001334545
NP_001334546
NP_695020

Location (UCSC)Chr 17: 81.9 – 81.9 MbChr 11: 120.5 – 120.5 Mb
PubMed search
Wikidata
View/Edit HumanView/Edit Mouse

Neuropeptide B is a short biologically active peptide whose precursor in humans is encoded by the NPB gene. Neuropeptide B acts via two G protein-coupled receptors, neuropeptide B/W receptors, called NPBW1 and NPBW2 encoded by the genes NPBWR1 and NPBWR2, respectively. Neuropeptide B is thought to be associated with the regulation of feeding, neuroendocrine system, memory, learning and in the afferent pain pathway. It is expressed throughout the central nervous system with high levels in the substantia nigra, hypothalamus, hippocampus, and spinal cord.

Function

The functions of neuropeptide B mirror the functions of the closely related neuropeptide W in many respects, as they bind to the same receptor targets but differ mainly in their levels of expression in different tissues, and when and how they are released. However, while neuropeptide W binds to both NPBW1 and NPBW2 with similar affinity, neuropeptide B is relatively selective for NPBW1 and binds only weakly to NPBW2. Central actions of neuropeptide B include regulation of appetite and energy homeostasis, reproductive behavior, pain, anxiety, and emotions. Peripheral actions include regulating secretion of adrenal hormones, and various regulatory roles in pancreatic beta cells and adipose tissue.

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000183979 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000044034 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Singh G, Davenport AP (Aug 2006). "Neuropeptide B and W: neurotransmitters in an emerging G-protein-coupled receptor system". British Journal of Pharmacology. 148 (8): 1033–1041. doi:10.1038/sj.bjp.0706825. PMC 1752024. PMID 16847439.
  6. ↑ Hondo M, Ishii M, Sakurai T (2008). "The NPB/NPW Neuropeptide System and Its Role in Regulating Energy Homeostasis, Pain, and Emotion". Orphan G Protein-Coupled Receptors and Novel Neuropeptides. Results and Problems in Cell Differentiation. Vol. 46. pp. 239–256. doi:10.1007/400_2007_056. ISBN 978-3-540-78350-3. PMID 18204824.
  7. ↑ Watanabe N, Yamamoto M (2015). "Neural mechanisms of social dominance". Frontiers in Neuroscience. 9: 154. doi:10.3389/fnins.2015.00154. PMC 4469834. PMID 26136644.
  8. ↑ Chottova Dvorakova M (2018). "Distribution and Function of Neuropeptides W/B Signaling System". Frontiers in Physiology. 9 981. doi:10.3389/fphys.2018.00981. PMC 6067035. PMID 30087623.
  9. ↑ Wojciechowicz T, Kolodziejski PA, Billert M, Strowski MZ, Nowak KW, Skrzypski M (March 2023). "The Effects of Neuropeptide B on Proliferation and Differentiation of Porcine White Preadipocytes into Mature Adipocytes". International Journal of Molecular Sciences. 24 (7): 6096. doi:10.3390/ijms24076096. PMC 10094185. PMID 37047072.
  10. ↑ Wojciechowicz T, Billert M, Jasaszwili M, Strowski MZ, Nowak KW, Skrzypski M (June 2021). "The Role of Neuropeptide B and Its Receptors in Controlling Appetite, Metabolism, and Energy Homeostasis". International Journal of Molecular Sciences. 22 (12): 6632. doi:10.3390/ijms22126632. PMC 8234850. PMID 34205710.
  11. ↑ Watanabe Y, Iwata K, Minabe S, Nakao N, Ishii H, Ozawa H (October 2023). "Central injection of neuropeptide B induces luteinizing hormone release in male and female rats". Peptides. 168 171064. doi:10.1016/j.peptides.2023.171064. PMID 37507090.
  12. ↑ Stein G, Aly JS, Lange L, Manzolillo A, Riege K, Brancato A, et al. (May 2025). "Npbwr1 signaling mediates fast antidepressant action". Molecular Psychiatry. 30 (5): 1828–1835. doi:10.1038/s41380-024-02790-4. PMC 12015170. PMID 39433904.