Propylphenidate

Propylphenidate
Legal status
Legal status
Identifiers
  • Propyl 2-phenyl-2-(piperidin-2-yl)acetate
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC16H23NO2
Molar mass261.365 g·mol−1
3D model (JSmol)
  • C1(=CC=CC=C1)C(C(=O)OCCC)C2CCCCN2
  • InChI=1S/C16H23NO2/c1-2-12-19-16(18)15(13-8-4-3-5-9-13)14-10-6-7-11-17-14/h3-5,8-9,14-15,17H,2,6-7,10-12H2,1H3
  • Key:PRMWWEANNQSWAR-UHFFFAOYSA-N

Propylphenidate (also known as PPH) is a piperidine based stimulant drug, closely related to methylphenidate, but with the methyl ester replaced by a propyl ester. It was banned in the UK as a Temporary Class Drug from April 2015 following its unapproved sale as a designer drug.

Pharmacology

Pharmacodynamics

Propylphenidate binds to the norepinephrine transporter in human embryonic kidney cells with an affinity similar to that of isopropylphenidate and ethylphenidate. However, its binding affinity for the dopamine transporter is 4 times lower, making it one of the methylphenidate analogues with the weakest affinity for DAT. On drug user forums, its subjective effects are described as very mild.

Propylphenidate is illegal in Sweden as of 26 January 2016, and in Finland since 2017.

See also

References

  1. ↑ "Methylphenidate-based NPS: A review of the evidence of use and harm. Advisory Council on the Misuse of Drugs, 31 March 2015" (PDF). www.gov.uk.
  2. ↑ Carlier J, Giorgetti R, Varì MR, Pirani F, Ricci G, Busardò FP (January 2019). "Use of cognitive enhancers: methylphenidate and analogs". European Review for Medical and Pharmacological Sciences. 23 (1): 3–15. doi:10.26355/eurrev_201901_16741. PMID 30657540.
  3. ↑ "31 nya ämnen kan klassas som narkotika eller hälsofarlig vara" (in Swedish). Folkhälsomyndigheten. November 2015.
  4. ↑ "Valtioneuvoston asetus kuluttajamarkkinoilta kielletyistä psykoaktiivisista aineista". Archived from the original on 2023-05-01. Retrieved 2021-06-07.