Fencamine

Fencamine
Clinical data
Other namesMethamphetaminoethylcaffeine
Routes of
administration		Oral
Drug classStimulant
ATC code
  • none
Identifiers
  • 1,3,7-trimethyl-8-({2-[methyl(1-phenylpropan-2-yl)amino]ethyl}amino)-3,7-dihydro-1H-purine-2,6-dione
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC20H28N6O2
Molar mass384.484 g·mol−1
3D model (JSmol)
  • O=C2N(c1nc(n(c1C(=O)N2C)C)NCCN(C(C)Cc3ccccc3)C)C

Fencamine, also known as methamphetaminoethylcaffeine, is a psychostimulant drug of the amphetamine class. It is closely related to fenethylline. It is metabolized to methamphetamine and amphetamine. The drug also contains a caffeine moiety in its chemical structure.

Fencamine has been experimentally used in the treatment of depression. A clinical report on its use in prolonged reactive depression, an older psychiatric term referring to depressive conditions attributed to psychological stressors, was published in 1970.

A 1974 study described a method for determining fencamine in rat and human urine. According to a 2000 review summarizing the human results, approximately 32% of a 50 mg dose was excreted unchanged in urine within 48 hours.

Names

The National Center for Advancing Translational Sciences Inxight Drugs database lists Altimina and Sicoclor as names for fencamine hydrochloride.

Yet the United Nations Office on Drugs and Crime's Multilingual Dictionary of Narcotic Drugs and Psychotropic Substances lists these names under fencamfamin.

Sicoclor was a registered medicinal product in Argentina until 2011.

See also

References

  1. ↑ Cody JT (May 2002). "Precursor medications as a source of methamphetamine and/or amphetamine positive drug testing results". Journal of Occupational and Environmental Medicine. 44 (5): 435–50. doi:10.1097/00043764-200205000-00012. PMID 12024689. S2CID 44614179.
  2. 1 2 3 Musshoff F (February 2000). "Illegal or legitimate use? Precursor compounds to amphetamine and methamphetamine". Drug Metab Rev. 32 (1): 15–44. doi:10.1081/dmr-100100562. PMID 10711406.
  3. ↑ Quirós e Isla, P. G. (15 December 1970). "Acción del derivado etilendiamínico, fencamina, sobre depresiones reactivas prolongadas" [Effect of the ethylenediamine derivative, fencamine, on prolonged reactive depression]. Revista Clínica Española (in Spanish). 119 (5): 437–438. PMID 5505078.
  4. ↑ Mallol J, Pitarch L, Coronas R, Pons A Jr (September 1974). "Determination of dl-fencamine in rat and human urine". Arzneimittelforschung. 24 (9): 1301–1304. PMID 4154765.
  5. ↑ "Fencamine hydrochloride". Inxight Drugs. National Center for Advancing Translational Sciences. Retrieved 2026-09-23.
  6. ↑ United Nations Office on Drugs and Crime. "Part One". Multilingual Dictionary of Narcotic Drugs and Psychotropic Substances (PDF). p. 129.
  7. ↑ "Disposición 3520/2011" (PDF) (in Spanish). Administración Nacional de Medicamentos, Alimentos y Tecnología Médica. 17 May 2011. p. 4. Retrieved 25 September 2026.