2C-Se

2C-Se
Clinical data
Other names4-Methylseleno-2,5-dimethoxyphenethylamine;
Routes of
administration		Oral
Drug classSerotonergic psychedelic; Hallucinogen
ATC code
  • None
Pharmacokinetic data
Onset of action45 minutes
Duration of action6–8 hours
Identifiers
  • 2-[2,5-dimethoxy-4-(methylselanyl)phenyl]ethan-1-amine
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC11H17NO2Se
Molar mass274.233 g·mol−1
3D model (JSmol)
Melting point240 to 241 °C (464 to 466 °F)
  • COC1=CC(=C(C=C1CCN)OC)[Se]C
  • InChI=1S/C11H17NO2Se/c1-13-9-7-11(15-3)10(14-2)6-8(9)4-5-12/h6-7H,4-5,12H2,1-3H3
  • Key:CXQUHXATPUFGMC-UHFFFAOYSA-N

2C-Se, also known as 4-methylseleno-2,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and 2C families.

It was originally named by Alexander Shulgin as described in his book PiHKAL (Phenethylamines I Have Known and Loved). Shulgin listed its dose as perhaps 100 mg orally and its duration as 6 to 8 hours. Its onset was 45 minutes, peak effects occurred after 1.5 hours, and doses of 50 to 70 mg orally produced threshold effects. Shulgin considered 2C-Se to be around three times the potency of mescaline, but was too concerned about toxicity to test it extensively, though he considered it noteworthy as the only psychedelic drug to contain a selenium atom.

The chemical synthesis of 2C-Se has been described.

2C-Se was first described in the literature by Shulgin in PiHKAL in 1991. It is a controlled substance in Canada under phenethylamine blanket-ban language.

See also

References

  1. 1 2 3 4 5 6 7 8 9 10 11 Shulgin A, Shulgin A (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628.
  2. 1 2 Shulgin A, Manning T, Daley PF (2011). The Shulgin Index. Volume 1. Psychedelic Phenethylamines and Related Compounds. Transform Press. p. 346. ISBN 978-0-9630096-3-0.
  3. 1 2 Shulgin AT (2003). "Basic Pharmacology and Effects". In Laing RR (ed.). Hallucinogens: A Forensic Drug Handbook. Forensic Drug Handbook Series. Elsevier Science. pp. 67–137. ISBN 978-0-12-433951-4. Retrieved 1 February 2025.
  4. 1 2 Trachsel D, Lehmann D, Enzensperger C (2013). Phenethylamine: Von der Struktur zur Funktion. Nachtschatten Verlag AG. pp. 801–802. ISBN 978-3-03788-700-4.
  5. 1 2 Jacob P, Shulgin AT (1994). "Structure-activity relationships of the classic hallucinogens and their analogs". NIDA Research Monograph. 146: 74–91. PMID 8742795. NIH Publication 94-3872.
  6. ↑ "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.