SERPINA9

SERPINA9
Identifiers
Aliases	SERPINA9, GCET1, SERPINA11, SERPINA11b, serpin family A member 9
External IDs	OMIM: 615677; MGI: 1919157; GeneCards: SERPINA9
Gene location (Human)
Chr.	Chromosome 14 (human)
End	94,479,689 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	103,980,014 bp
RNA expression pattern
	Top expressed in
	epithelium of nasopharynx; ; testicle; ; lymph node; ; appendix; ; superior surface of tongue; ; oral cavity; ; tonsil; ; skin of abdomen; ; skin of leg; ; gonad;
	Top expressed in
	striatum of neuraxis; ; esophagus; ; lip; ; superior frontal gyrus; ; exocrine gland; ; liver; ; visual cortex; ; cerebellum; ; cerebellar cortex; ; primary visual cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase inhibitor activity; serine-type endopeptidase inhibitor activity;
Cellular component	extracellular region; membrane; cytoplasm; extracellular space;
Biological process	negative regulation of peptidase activity; negative regulation of endopeptidase activity;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	327657
	71907
	ENSG00000170054
	ENSMUSG00000058260
	Q86WD7
	Q9D7D2
	NM_001042518; NM_001284275; NM_001284276; NM_175739
	NM_027997; NM_001361910; NM_001361912
	NP_001035983; NP_001271204; NP_001271205; NP_783866
	NP_082273; NP_001348839; NP_001348841
	Wikidata
View/Edit Human	View/Edit Mouse

Serpin A9 also known as centerin or GCET1 is a protein that in humans is encoded by the SERPINA9 gene located on chromosome 14q32.1. Serpin A9 is a member of the serpin family of serine protease inhibitors.

Function

The expression of SERPINA9 is restricted to germinal center B cells and lymphoid malignancies. SERPINA9 is likely to function in vivo in the germinal center as an efficient inhibitor of trypsin-like proteases.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000170054 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000058260 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: SERPINA9".
↑ Paterson MA, Horvath AJ, Pike RN, Coughlin PB (August 2007). "Molecular characterization of centerin, a germinal centre cell serpin". Biochem. J. 405 (3): 489–94. doi:10.1042/BJ20070174. PMC 2267310. PMID 17447896.
↑ Montes-Moreno S, Roncador G, Maestre L, Martínez N, Sanchez-Verde L, Camacho FI, Cannata J, Martinez-Torrecuadrada JL, Shen Y, Chan WC, Piris MA (January 2008). "Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas". Blood. 111 (1): 351–8. doi:10.1182/blood-2007-06-094151. PMID 17898315.
↑ Paterson MA, Hosking PS, Coughlin PB (July 2008). "Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas". Am. J. Clin. Pathol. 130 (1): 117–26. doi:10.1309/9QKE68QU7B825A3U. PMID 18550480.

External links

The MEROPS online database for peptidases and their inhibitors: I04.082 Deprecated link archived 2012-12-23 at archive.today
SERPINA9+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000170054 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000058260 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SERPINA9".

[pmid17447896-6] Paterson MA, Horvath AJ, Pike RN, Coughlin PB (August 2007). "Molecular characterization of centerin, a germinal centre cell serpin". Biochem. J. 405 (3): 489–94. doi:10.1042/BJ20070174. PMC 2267310. PMID 17447896.

[pmid17898315-7] Montes-Moreno S, Roncador G, Maestre L, Martínez N, Sanchez-Verde L, Camacho FI, Cannata J, Martinez-Torrecuadrada JL, Shen Y, Chan WC, Piris MA (January 2008). "Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas". Blood. 111 (1): 351–8. doi:10.1182/blood-2007-06-094151. PMID 17898315.

[pmid18550480-8] Paterson MA, Hosking PS, Coughlin PB (July 2008). "Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas". Am. J. Clin. Pathol. 130 (1): 117–26. doi:10.1309/9QKE68QU7B825A3U. PMID 18550480.

v t e Serpins
inhibitory	Alpha 1-antichymotrypsin Alpha-1 antitrypsin Alpha 2-antiplasmin Antithrombin C1-inhibitor CU-2010 and CU-2020 Heparin cofactor II Protein C inhibitor Plasminogen activator inhibitor-1 Plasminogen activator inhibitor-2 Protein Z-related protease inhibitor SERPINA1 SERPINA2 SERPINA3 SERPINA4 SERPINA5 SERPINA9 SERPINA14 SERPINB1 SERPINB2 SERPINB3 SERPINB4 SERPINB5 SERPINB6 SERPINB7 SERPINB8 SERPINB9 SERPINB10 SERPINB13 SERPINC1 SERPIND1 SERPINE1 SERPINE2 SERPINE2 SERPINF1 SERPING1 SERPINH1 SERPINI1 SERPINI2
Cross class inhibitory	MENT SCCA-1 CrmA
noninhibitory	Heat shock protein 47 Maspin Ovalbumin Transcortin Thyroxine-binding globulin Angiotensinogen PEDF
see also disorders of globin and globulin proteins

SERPINA9

Function

References

Further reading

External links