Mitochondrial ornithine transporter 1

SLC25A15
Identifiers
Aliases	SLC25A15, D13S327, HHH, ORC1, ORNT1, solute carrier family 25 member 15, LNC-HC
External IDs	OMIM: 603861; MGI: 1342274; GeneCards: SLC25A15
Gene location (Human) Chr. Chromosome 13 (human) Band 13q14.11 Start 40,789,412 bp End 40,812,460 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8|8 A2 Start 22,865,567 bp End 22,888,613 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in liver right lobe of liver duodenum jejunal mucosa body of pancreas testicle gonad mucosa of ileum stromal cell of endometrium thyroid gland Top expressed in epithelium of small intestine left lobe of liver Ileal epithelium Paneth cell jejunum migratory enteric neural crest cell primary oocyte human kidney right kidney proximal tubule More reference expression data BioGPS n/a
Gene ontology Molecular function L-ornithine transmembrane transporter activity transmembrane transporter activity Cellular component membrane mitochondrion mitochondrial inner membrane integral component of membrane Biological process urea cycle mitochondrial transport mitochondrial L-ornithine transmembrane transport Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 10166 18408 Ensembl ENSG00000102743 ENSMUSG00000031482 UniProt Q9Y619 Q9WVD5 RefSeq (mRNA) NM_014252 NM_181325 NM_001358971 RefSeq (protein) NP_055067 NP_851842 NP_001345900 Location (UCSC) Chr 13: 40.79 – 40.81 Mb Chr 8: 22.87 – 22.89 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Mitochondrial ornithine transporter 1 is a protein that in humans is encoded by the SLC25A15 gene. It is responsible for transporting ornithine from the cytosol into the mitochondria in the urea cycle. In humans, it is highly expressed in the liver and pancreas, unlike the related Mitochondrial ornithine transporter 2 (SLC25A2) which is instead expressed primarily in the testis.

Pathology

A disorder is associated with ornithine translocase deficiency, and a form of hyperammonemia.

See also

• Translocase

References

External links

• ornithine+translocase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• SLC25A15 human gene location in the UCSC Genome Browser.
• SLC25A15 human gene details in the UCSC Genome Browser.

This membrane protein–related article is a stub. You can help Wikipedia by adding missing information.

• v
• t
• e