GDP-fucose transporter 1

SLC35C1
Identifiers
Aliases	SLC35C1, CDG2C, FUCT1, solute carrier family 35 member C1
External IDs	OMIM: 605881; MGI: 2443301; GeneCards: SLC35C1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	45,813,016 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	92,290,883 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; mucosa of transverse colon; ; minor salivary glands; ; stromal cell of endometrium; ; mucosa of pharynx; ; mucosa of ileum; ; subcutaneous adipose tissue; ; buccal mucosa cell; ; granulocyte; ; gonad;
	Top expressed in
	colon; ; left colon; ; pyloric antrum; ; epithelium of stomach; ; lacrimal gland; ; crypt of lieberkuhn of small intestine; ; yolk sac; ; granulocyte; ; duodenum; ; mucous cell of stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GDP-fucose transmembrane transporter activity; antiporter activity; transmembrane transporter activity;
Cellular component	integral component of membrane; Golgi membrane; Golgi apparatus; membrane;
Biological process	lipid glycosylation; negative regulation of Notch signaling pathway; carbohydrate transport; GDP-fucose import into Golgi lumen; protein O-linked fucosylation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	55343
	228368
	ENSG00000181830
	ENSMUSG00000049922
	Q96A29
	Q8BLX4
	NM_001145265; NM_001145266; NM_018389
	NM_145832; NM_211358
	NP_001138737; NP_001138738; NP_060859
	NP_665831; NP_997597
	Wikidata
View/Edit Human	View/Edit Mouse

GDP-fucose transporter 1 is a protein that in humans is encoded by the SLC35C1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000181830 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000049922 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Luhn K, Wild MK, Eckhardt M, Gerardy-Schahn R, Vestweber D (Apr 2001). "The gene defective in leukocyte adhesion deficiency II encodes a putative GDP-fucose transporter". Nat Genet. 28 (1): 69–72. doi:10.1038/88289. PMID 11326279.
↑ Lubke T, Marquardt T, Etzioni A, Hartmann E, von Figura K, Korner C (Apr 2001). "Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency". Nat Genet. 28 (1): 73–6. doi:10.1038/88299. PMID 11326280.
↑ "Entrez Gene: SLC35C1 solute carrier family 35, member C1".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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