Sodium/hydrogen exchanger 10

SLC9C1
Identifiers
Aliases	SLC9C1, NHE, SLC9A10, sperm-NHE, NHE-10, solute carrier family 9 member C1
External IDs	OMIM: 612738; MGI: 2685456; GeneCards: SLC9C1
Gene location (Human)
Chr.	Chromosome 3 (human)
End	112,294,227 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	45,427,364 bp
RNA expression pattern
	Top expressed in
	testicle; ; body of pancreas; ; left testis; ; right testis; ; gonad; ; skin of abdomen; ; skin of leg; ; left ventricle; ; apex of heart; ; left lobe of thyroid gland;
	Top expressed in
	spermatocyte; ; spermatid; ; testicle; ; islet of Langerhans;
	More reference expression data
	n/a
Gene ontology
Molecular function	solute:proton antiporter activity; antiporter activity; potassium:proton antiporter activity; sodium:proton antiporter activity; ion channel activity;
Cellular component	integral component of membrane; cell projection; motile cilium; cilium; membrane; plasma membrane;
Biological process	multicellular organism development; proton transmembrane transport; flagellated sperm motility; cell differentiation; cation transport; ion transport; spermatogenesis; sodium ion transport; regulation of intracellular pH; sodium ion import across plasma membrane; potassium ion transmembrane transport; transmembrane transport; anion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	285335
	208169
	ENSG00000172139; ENSG00000285044
	ENSMUSG00000033210
	Q4G0N8
	Q6UJY2
	NM_183061; NM_001320531
	NM_198106
	NP_001307460; NP_898884
	NP_932774
	Wikidata
View/Edit Human	View/Edit Mouse

Sodium/hydrogen exchanger 10, also known as Solute carrier family 9 member C1, is a protein that in humans is encoded by the gene SLC9C1 (previously SLC9A10).

Function

SLC9C1 is a member of the sodium-hydrogen exchanger (NHE) family and is required for male fertility and sperm motility.

References

1 2 3 ENSG00000285044 GRCh38: Ensembl release 89: ENSG00000172139, ENSG00000285044 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033210 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: solute carrier family 9".
↑ Oduru S, Campbell JL, Karri S, Hendry WJ, Khan SA, Williams SC (June 2003). "Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs". BMC Genomics. 4 (1): 22. doi:10.1186/1471-2164-4-22. PMC 161800. PMID 12783626.
↑ Wang D, King SM, Quill TA, Doolittle LK, Garbers DL (December 2003). "A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility". Nature Cell Biology. 5 (12): 1117–22. doi:10.1038/ncb1072. PMID 14634667. S2CID 12912080.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 ENSG00000285044 GRCh38: Ensembl release 89: ENSG00000172139, ENSG00000285044 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033210 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: solute carrier family 9".

[pmid12783626-6] Oduru S, Campbell JL, Karri S, Hendry WJ, Khan SA, Williams SC (June 2003). "Gene discovery in the hamster: a comparative genomics approach for gene annotation by sequencing of hamster testis cDNAs". BMC Genomics. 4 (1): 22. doi:10.1186/1471-2164-4-22. PMC 161800. PMID 12783626.

[pmid14634667-7] Wang D, King SM, Quill TA, Doolittle LK, Garbers DL (December 2003). "A new sperm-specific Na+/H+ exchanger required for sperm motility and fertility". Nature Cell Biology. 5 (12): 1117–22. doi:10.1038/ncb1072. PMID 14634667. S2CID 12912080.