Sodium/hydrogen exchanger 5

SLC9A5

Identifiers

SLC9A5, NHE5, solute carrier family 9 member A5

External IDs

OMIM: 600477; MGI: 2685542; GeneCards: SLC9A5

Gene location (Human)

Chr.	Chromosome 16 (human)

Band	16q22.1	Start	67,237,683 bp
Band	16q22.1	End	67,272,191 bp

Gene location (Mouse)

Chr.	Chromosome 8 (mouse)

Band	8\|8 D3	Start	105,348,843 bp
Band	8\|8 D3	End	105,369,881 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

right hemisphere of cerebellum

spleen

stromal cell of endometrium

nucleus accumbens

putamen

caudate nucleus

cerebellar vermis

testicle

right frontal lobe

dorsal motor nucleus of vagus nerve

Top expressed in

spermatocyte

superior frontal gyrus

cerebellar cortex

neural layer of retina

primary visual cortex

lumbar subsegment of spinal cord

seminiferous tubule

tail of embryo

ventricular zone

cerebellar vermis

More reference expression data


More reference expression data

Gene ontology
Molecular function	solute:proton antiporter activity antiporter activity potassium:proton antiporter activity sodium:proton antiporter activity
Cellular component	membrane integral component of membrane plasma membrane
Biological process	regulation of pH ion transport proton transmembrane transport sodium ion transport cation transport regulation of intracellular pH sodium ion import across plasma membrane potassium ion transmembrane transport transmembrane transport anion transmembrane transport
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


6553


277973


ENSG00000135740


ENSMUSG00000014786


Q14940


B2RXE2

RefSeq (mRNA)

NM_004594 NM_001323971 NM_001323972 NM_001323973 NM_001323974
NM_001323975


NM_001081332

RefSeq (protein)

NP_001310900 NP_001310901 NP_001310902 NP_001310903 NP_001310904
NP_004585


NP_001074801

Location (UCSC)

Chr 16: 67.24 – 67.27 Mb

Chr 8: 105.35 – 105.37 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Sodium/hydrogen exchanger 5 is a protein that in humans is encoded by the SLC9A5 gene.

See also

Solute carrier family

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000135740 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014786 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Klanke CA, Su YR, Callen DF, Wang Z, Meneton P, Baird N, Kandasamy RA, Orlowski J, Otterud BE, Leppert M, et al. (Jun 1995). "Molecular cloning and physical and genetic mapping of a novel human Na+/H+ exchanger (NHE5/SLC9A5) to chromosome 16q22.1". Genomics. 25 (3): 615–22. doi:10.1016/0888-7543(95)80002-4. PMID 7759094.
↑ Attaphitaya S, Park K, Melvin JE (Mar 1999). "Molecular cloning and functional expression of a rat Na+/H+ exchanger (NHE5) highly expressed in brain". J Biol Chem. 274 (7): 4383–8. doi:10.1074/jbc.274.7.4383. PMID 9933642.
↑ "Entrez Gene: SLC9A5 solute carrier family 9 (sodium/hydrogen exchanger), member 5".

Further reading

Baird NR, Orlowski J, Szabó EZ, et al. (1999). "Molecular cloning, genomic organization, and functional expression of Na+/H+ exchanger isoform 5 (NHE5) from human brain". J. Biol. Chem. 274 (7): 4377–82. doi:10.1074/jbc.274.7.4377. PMID 9933641.
Szaszi K, Paulsen A, Szabo EZ, et al. (2003). "Clathrin-mediated endocytosis and recycling of the neuron-specific Na+/H+ exchanger NHE5 isoform. Regulation by phosphatidylinositol 3'-kinase and the actin cytoskeleton". J. Biol. Chem. 277 (45): 42623–32. doi:10.1074/jbc.M206629200. hdl:20.500.14905/80594. PMID 12205089.
Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". Am. J. Hum. Genet. 71 (6): 1443–9. doi:10.1086/344580. PMC 378590. PMID 12417987.
Inoue H, Nakamura Y, Nagita M, et al. (2003). "Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium". Biol. Pharm. Bull. 26 (2): 148–55. doi:10.1248/bpb.26.148. PMID 12576672.
Lin WM, Chen XH, Xu R, et al. (2003). "[Tissue-specific expression of Na(+)-H(+) exchanger isoforms at two developmental stages of human fetus]". Sheng li xue bao: [Acta Physiologica Sinica]. 55 (1): 79–82. PMID 12598940.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Szabó EZ, Numata M, Lukashova V, et al. (2005). "beta-Arrestins bind and decrease cell-surface abundance of the Na+/H+ exchanger NHE5 isoform". Proc. Natl. Acad. Sci. U.S.A. 102 (8): 2790–5. Bibcode:2005PNAS..102.2790S. doi:10.1073/pnas.0407444102. PMC 549460. PMID 15699339.
Onishi I, Lin PJ, Diering GH, et al. (2007). "RACK1 associates with NHE5 in focal adhesions and positively regulates the transporter activity". Cell. Signal. 19 (1): 194–203. doi:10.1016/j.cellsig.2006.06.011. PMID 16920332.

Membrane proteins, carrier proteins: membrane transport proteins solute carrier (TC 2A)

By group

SLC1–10

(1):	High affinity glutamate and neutral amino-acid transporter SLC1A1 SLC1A2 SLC1A3 SLC1A4 SLC1A5 SLC1A6 SLC1A7
(2):	Facilitative GLUT transporter SLC2A1 SLC2A2 SLC2A3 SLC2A4 SLC2A5 SLC2A6 SLC2A7 SLC2A8 SLC2A9 SLC2A10 SLC2A11 SLC2A12 SLC2A13 SLC2A14
(3):	Heavy subunits of heterodimeric amino-acid transporters SLC3A1 SLC3A2
(4):	Bicarbonate transporter SLC4A1 SLC4A2 SLC4A3 SLC4A4 SLC4A5 SLC4A6 SLC4A7 SLC4A8 SLC4A9 SLC4A10 SLC4A11
(5):	Sodium glucose cotransporter SLC5A1 SLC5A2 SLC5A3 SLC5A4 SLC5A5 SLC5A6 SLC5A7 SLC5A8 SLC5A9 SLC5A10 SLC5A11 SLC5A12
(6):	Sodium- and chloride- dependent sodium:neurotransmitter symporters SLC6A1 SLC6A2 SLC6A3 SLC6A4 SLC6A5 SLC6A6 SLC6A7 SLC6A8 SLC6A9 SLC6A10 SLC6A11 SLC6A12 SLC6A13 SLC6A14 SLC6A15 SLC6A16 SLC6A17 SLC6A18 SLC6A19 SLC6A20
(7):	Cationic amino-acid transporter/glycoprotein-associated SLC7A1 SLC7A2 SLC7A3 SLC7A4 Glycoprotein-associated/light or catalytic subunits of heterodimeric amino-acid transporters SLC7A5 SLC7A6 SLC7A7 SLC7A8 SLC7A9 SLC7A10 SLC7A11 SLC7A13 SLC7A14
(8):	Na⁺/Ca²⁺ exchanger SLC8A1 SLC8A2 SLC8A3
(9):	Na⁺/H⁺ exchanger SLC9A1 SLC9A2 SLC9A3 SLC9A4 SLC9A5 SLC9A6 SLC9A7 SLC9A8 SLC9A9 SLC9A10 SLC9A11
(10):	Sodium bile salt cotransport SLC10A1 SLC10A2 SLC10A3 SLC10A4 SLC10A5 SLC10A6 SLC10A7

SLC11–20

(11):	Proton coupled metal ion transporter SLC11A1 SLC11A2 SLC11A3
(12):	Electroneutral cation-Cl cotransporter SLC12A1 SLC12A2 SLC12A3 SLC12A4 SLC12A5 SLC12A6 SLC12A7 SLC12A8 SLC12A9
(13):	human Na⁺-sulfate/carboxylate cotransporter SLC13A1 SLC13A2 SLC13A3 SLC13A4 SLC13A5
(14):	Urea transporter SLC14A1 SLC14A2
(15):	Proton oligopeptide cotransporter SLC15A1 SLC15A2 SLC15A3 SLC15A4
(16):	Monocarboxylate transporter SLC16A1 SLC16A2 SLC16A3 SLC16A4 SLC16A5 SLC16A6 SLC16A7 SLC16A8 SLC16A9 SLC16A10 SLC16A11 SLC16A12 SLC16A13 SLC16A14
(17):	Vesicular glutamate transporter 1 SLC17A1 SLC17A2 SLC17A3 SLC17A4 SLC17A5 SLC17A6 SLC17A7 SLC17A8 SLC17A9
(18):	Vesicular monoamine transporter SLC18A1 SLC18A2 SLC18A3
(19):	Folate/thiamine transporter SLC19A1 SLC19A2 SLC19A3
(20):	Type III Na⁺-phosphate cotransporter SLC20A1 SLC20A2

SLC21–30

(21):	Organic anion-transporting polypeptide SLCO1A2 SLCO1B1 SLCO1B3 SLCO1B4 SLCO1C1 SLCO2A1 SLCO2B1 SLCO3A1 SLCO4A1 SLCO4C1 SLCO5A1 SLCO6A1
(22):	Organic cation/anion/zwitterion transporter SLC22A1 SLC22A2 SLC22A3 SLC22A4 SLC22A5 SLC22A6 SLC22A7 SLC22A8 SLC22A9 SLC22A10 SLC22A11 SLC22A12 SLC22A13 SLC22A14 SLC22A15 SLC22A16 SLC22A17 SLC22A18 SLC22A20 SLC22A25
(23):	Na+-dependent ascorbic acid transporter SLC23A1 SLC23A2 SLC23A3 SLC23A4
(24):	Na⁺/(Ca²⁺-K⁺) exchanger SLC24A1 SLC24A2 SLC24A3 SLC24A4 SLC24A5 SLC24A6
(25):	Mitochondrial carrier SLC25A1 SLC25A2 SLC25A3 SLC25A4 SLC25A5 SLC25A6 SLC25A7 SLC25A8 SLC25A9 SLC25A10 SLC25A11 SLC25A12 SLC25A13 SLC25A14 SLC25A15 SLC25A16 SLC25A17 SLC25A18 SLC25A19 SLC25A20 SLC25A21 SLC25A22 SLC25A23 SLC25A24 SLC25A25 SLC25A26 SLC25A27 SLC25A28 SLC25A29 SLC25A30 SLC25A31 SLC25A32 SLC25A33 SLC25A34 SLC25A35 SLC25A36 SLC25A37 SLC25A38 SLC25A39 SLC25A40 SLC25A41 SLC25A42 SLC25A43 SLC25A44 SLC25A45 SLC25A46
(26):	Multifunctional anion exchanger SLC26A1 SLC26A2 SLC26A3 SLC26A4 SLC26A5 SLC26A6 SLC26A7 SLC26A8 SLC26A9 SLC26A10 SLC26A11
(27):	Fatty acid transport proteins SLC27A1 SLC27A2 SLC27A3 SLC27A4 SLC27A5 SLC27A6
(28):	Na⁺-coupled nucleoside transport SLC28A1 SLC28A2 SLC28A3
(29):	Facilitative nucleoside transporter SLC29A1 SLC29A2 SLC29A3 SLC29A4
(30):	Zinc efflux SLC30A1 SLC30A2 SLC30A3 SLC30A4 SLC30A5 SLC30A6 SLC30A7 SLC30A8 SLC30A9 SLC30A10

SLC31–40

(31):	Copper transporter SLC31A1
(32):	Vesicular glutamate transporter 1 SLC32A1
(33):	Acetyl-CoA transporter SLC33A1
(34):	type II Na⁺-phosphate cotransporter SLC34A1 SLC34A2 SLC34A3
(35):	Nucleoside-sugar transporter SLC35A1 SLC35A2 SLC35A3 SLC35A4 SLC35A5 SLC35B1 SLC35B2 SLC35B3 SLC35B4 SLC35C1 SLC35C2 SLC35D1 SLC35D2 SLC35D3 SLC35E1 SLC35E2 SLC35E3 SLC35E4
(36):	Proton coupled amino acid transporter SLC36A1 SLC36A2 SLC36A3 SLC36A4
(37):	Sugar-phosphate/phosphate exchanger SLC37A1 SLC37A2 SLC37A3 SLC37A4
(38):	System A & N, sodium-coupled neutral amino-acid transporter SLC38A1 SLC38A2 SLC38A3 SLC38A4 SLC38A5 SLC38A6 SLC38A10
(39):	Metal ion transporter SLC39A1 SLC39A2 SLC39A3 SLC39A4 SLC39A5 SLC39A6 SLC39A7 SLC39A8 SLC39A9 SLC39A10 SLC39A11 SLC39A12 SLC39A13 SLC39A14
(40):	Basolateral iron transporter SLC40A1

SLC41–48

(41):	Magnesium transporter E SLC41A1 SLC41A2 SLC41A3
(42):	Ammonia transporter SLC42A1 SLC42A2 SLC42A3
(43):	Na⁺-independent, system-L like amino-acid transporter SLC43A1 SLC43A2 SLC43A3
(44):	Choline-like transporter SLC44A1 SLC44A2 SLC44A3 SLC44A4 SLC44A5
(45):	Putative sugar transporter SLC45A1 SLC45A2 SLC54A3 SLC45A4
(46):	Folate transporter SLC46A1 SLC46A2 SLC46A3
(47):	Multidrug and toxin extrusion SLC47A1 SLC47A2
(48):	Heme transporter

SLCO1–4
SLCO1A2 SLCO1B1 SLCO1B3 SLCO2B1 SLCO3A1 SLCO4A1

Symporter, Cotransporter	Na⁺/K⁺,Cl⁻ Na⁺/P_i3 Na⁺/Cl⁻ Na⁺/glucose Na⁺/I⁻ Cl⁻/K⁺ 4 5
Antiporter (exchanger)	Na⁺/H⁺ Na⁺/Ca²⁺ Na⁺/(Ca²⁺-K⁺) - Cl⁻/HCO⁻ ₃ (Band 3) Cl⁻-formate Cl⁻-oxalate

see also solute carrier disorders

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