SLCO2B1

SLCO2B1
Identifiers
Aliases	SLCO2B1, OATP-B, OATP2B1, OATPB, SLC21A9, solute carrier organic anion transporter family member 2B1
External IDs	OMIM: 604988; MGI: 1351872; GeneCards: SLCO2B1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	75,206,549 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	99,360,547 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; sural nerve; ; upper lobe of left lung; ; C1 segment; ; lymph node; ; spleen; ; mucosa of ileum; ; gallbladder; ; right adrenal cortex; ; appendix;
	Top expressed in
	left lobe of liver; ; mesenteric lymph nodes; ; sciatic nerve; ; lumbar subsegment of spinal cord; ; subcutaneous adipose tissue; ; white adipose tissue; ; spleen; ; skin of abdomen; ; stroma of bone marrow; ; extraocular muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	organic anion transmembrane transporter activity; transporter activity; sodium-independent organic anion transmembrane transporter activity; bile acid transmembrane transporter activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	ion transport; bile acid and bile salt transport; sodium-independent organic anion transport; transmembrane transport; transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	11309
	101488
	ENSG00000137491
	ENSMUSG00000030737
	O94956
	Q8BXB6
	NM_007256; NM_001145211; NM_001145212
	NM_001252530; NM_001252531; NM_175316
	NP_001138683; NP_001138684; NP_009187
	NP_001239459; NP_001239460; NP_780525
	Wikidata
View/Edit Human	View/Edit Mouse

Solute carrier organic anion transporter family member 2B1 also known as organic anion-transporting polypeptide 2B1 (OATP2B1) is a protein that in humans is encoded by the gene SLCO2B1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000137491 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030737 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: SLCO2B1 solute carrier organic anion transporter family, member 2B1".

Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (6): 355–64. doi:10.1093/dnares/5.6.355. PMID 10048485.
Tamai I, Nezu J, Uchino H, et al. (2000). "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family". Biochem. Biophys. Res. Commun. 273 (1): 251–60. doi:10.1006/bbrc.2000.2922. PMID 10873595.
St-Pierre MV, Hagenbuch B, Ugele B, et al. (2002). "Characterization of an organic anion-transporting polypeptide (OATP-B) in human placenta". J. Clin. Endocrinol. Metab. 87 (4): 1856–63. doi:10.1210/jcem.87.4.8431. PMID 11932330.
Nozawa T, Nakajima M, Tamai I, et al. (2002). "Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis". J. Pharmacol. Exp. Ther. 302 (2): 804–13. doi:10.1124/jpet.302.2.804. PMID 12130747.
Ugele B, St-Pierre MV, Pihusch M, et al. (2003). "Characterization and identification of steroid sulfate transporters of human placenta". Am. J. Physiol. Endocrinol. Metab. 284 (2): E390–8. doi:10.1152/ajpendo.00257.2002. PMID 12409283. S2CID 348962.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hänggi E, Grundschober AF, Leuthold S, et al. (2006). "Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1". Mol. Pharmacol. 70 (3): 806–17. doi:10.1124/mol.105.019547. PMID 16754786. S2CID 25002890.
Grube M, Köck K, Karner S, et al. (2006). "Modification of OATP2B1-mediated transport by steroid hormones". Mol. Pharmacol. 70 (5): 1735–41. doi:10.1124/mol.106.026450. PMID 16908597. S2CID 6327839.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000137491 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030737 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: SLCO2B1 solute carrier organic anion transporter family, member 2B1".

SLCO2B1

See also

References

Further reading