SNX1
Protein-coding gene in the species Homo sapiens
Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene . The protein encoded by this gene is a sorting nexin . SNX1 is a component of the retromer complex.
Further reading
Parks WT, Frank DB, Huff C, et al. (2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases" . J. Biol. Chem . 276 (22): 19332– 9. doi :10.1074/jbc.M100606200 PMID 11279102 . Cozier GE, Carlton J, McGregor AH, et al. (2002). "The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation" . J. Biol. Chem . 277 (50): 48730– 6. doi :10.1074/jbc.M206986200 PMID 12198132 . Shank BB, Wiley HS, Kurten RC (2001). "Structural and functional characterization of the human gene for sorting nexin 1 (SNX1)". DNA Cell Biol . 20 (5): 287– 96. doi :10.1089/104454901750232481 . PMID 11410165 . Liu H, Liu ZQ, Chen CX, et al. (2006). "Inhibitory regulation of EGF receptor degradation by sorting nexin 5". Biochem. Biophys. Res. Commun . 342 (2): 537– 46. Bibcode :2006BBRC..342..537L . doi :10.1016/j.bbrc.2006.01.179 . PMID 16487940 . Bryant DM, Kerr MC, Hammond LA, et al. (2007). "EGF induces macropinocytosis and SNX1-modulated recycling of E-cadherin". J. Cell Sci . 120 (Pt 10): 1818– 28. doi :10.1242/jcs.000653 . PMID 17502486 . S2CID 24175340 . Simpson F, Martin S, Evans TM, et al. (2005). "A novel hook-related protein family and the characterization of hook-related protein 1" . Traffic . 6 (6): 442– 58. doi :10.1111/j.1600-0854.2005.00289.x PMID 15882442 . S2CID 25389776 . Imabayashi H, Mori T, Gojo S, et al. (2003). "Redifferentiation of dedifferentiated chondrocytes and chondrogenesis of human bone marrow stromal cells via chondrosphere formation with expression profiling by large-scale cDNA analysis". Exp. Cell Res . 288 (1): 35– 50. doi :10.1016/S0014-4827(03)00130-7 . PMID 12878157 . Zhong Q, Watson MJ, Lazar CS, et al. (2005). "Determinants of the endosomal localization of sorting nexin 1" . Mol. Biol. Cell . 16 (4): 2049– 57. doi :10.1091/mbc.E04-06-0504 . PMC 1073682 PMID 15673616 . Mari M, Bujny MV, Zeuschner D, et al. (2008). "SNX1 defines an early endosomal recycling exit for sortilin and mannose 6-phosphate receptors" . Traffic . 9 (3): 380– 93. doi :10.1111/j.1600-0854.2007.00686.x PMID 18088323 . S2CID 31922423 . Nguyen LN, Holdren MS, Nguyen AP, et al. (2006). "Sorting nexin 1 down-regulation promotes colon tumorigenesis" . Clin. Cancer Res . 12 (23): 6952– 9. doi :10.1158/1078-0432.CCR-06-0317 hdl :11336/31768 PMID 17145813 . Pons V, Hullin-Matsuda F, Nauze M, et al. (2003). "Enterophilin-1, a new partner of sorting nexin 1, decreases cell surface epidermal growth factor receptor" . J. Biol. Chem . 278 (23): 21155– 61. doi :10.1074/jbc.M211008200 PMID 12657642 . Rojas R, Kametaka S, Haft CR, Bonifacino JS (2007). "Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors" . Mol. Cell. Biol . 27 (3): 1112– 24. doi :10.1128/MCB.00156-06 . PMC 1800681 PMID 17101778 . Gullapalli A, Wolfe BL, Griffin CT, et al. (2006). "An essential role for SNX1 in lysosomal sorting of protease-activated receptor-1: evidence for retromer-, Hrs-, and Tsg101-independent functions of sorting nexins" . Mol. Biol. Cell . 17 (3): 1228– 38. doi :10.1091/mbc.E05-09-0899 . PMC 1382312 PMID 16407403 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121– 7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Zhong Q, Lazar CS, Tronchère H, et al. (2002). "Endosomal localization and function of sorting nexin 1" . Proc. Natl. Acad. Sci. U.S.A . 99 (10): 6767– 72. Bibcode :2002PNAS...99.6767Z . doi :10.1073/pnas.092142699 PMC 124477 PMID 11997453 . Wang Y, Zhou Y, Szabo K, et al. (2002). "Down-regulation of protease-activated receptor-1 is regulated by sorting nexin 1" . Mol. Biol. Cell . 13 (6): 1965– 76. doi :10.1091/mbc.E01-11-0131 . PMC 117618 PMID 12058063 . Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899– 903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Carlton J, Bujny M, Peter BJ, et al. (2004). "Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides". Curr. Biol . 14 (20): 1791– 800. Bibcode :2004CBio...14.1791C . doi :10.1016/j.cub.2004.09.077 . hdl :1874/12362 PMID 15498486 . S2CID 10366991 . Kurten RC, Eddington AD, Chowdhury P, et al. (2001). "Self-assembly and binding of a sorting nexin to sorting endosomes" . J. Cell Sci . 114 (Pt 9): 1743– 56. doi :10.1242/jcs.114.9.1743 PMID 11309204 .
