ARHGAP33

ARHGAP33
Identifiers
Aliases	ARHGAP33, NOMA-GAP, SNX26, TCGAP, Rho GTPase activating protein 33
External IDs	OMIM: 614902; MGI: 2673998; GeneCards: ARHGAP33
Gene location (Human)
Chr.	Chromosome 19 (human)
End	35,788,822 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	30,535,060 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; right uterine tube; ; right hemisphere of cerebellum; ; right frontal lobe; ; C1 segment; ; anterior pituitary; ; right testis; ; left testis; ; right ovary;
	Top expressed in
	superior frontal gyrus; ; olfactory tubercle; ; piriform cortex; ; visual cortex; ; primary visual cortex; ; subiculum; ; nucleus accumbens; ; ganglionic eminence; ; ventricular zone; ; prefrontal cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphatidylinositol binding; protein binding; GTPase activator activity; protein kinase binding;
Cellular component	cytosol; cytoplasm; plasma membrane; cell cortex; actin cytoskeleton; protein-containing complex; dendritic spine;
Biological process	regulation of small GTPase mediated signal transduction; protein transport; positive regulation of GTPase activity; signal transduction; small GTPase mediated signal transduction; response to toxic substance; regulation of dendritic spine morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	115703
	233071
	ENSG00000004777
	ENSMUSG00000036882
	O14559
	Q80YF9
	NM_001172630; NM_052948; NM_001366178
	NM_001289670; NM_001289682; NM_178252
	NP_001166101; NP_443180; NP_001353107
	NP_001276599; NP_001276611; NP_839983
	Wikidata
View/Edit Human	View/Edit Mouse

Rho GTPase-activating protein 33 is a protein that in humans is encoded by the ARHGAP33 gene (previously SNX26). Predictions suggest that it may be involved in insulin signaling and glucose transport, potentially as a downstream effector of RHOQ.

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The specific function of this protein has not been elucidated. Alternative splice variants have been described but their full length nature has not been determined.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000004777 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036882 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Peck J, Douglas G IV, Wu CH, Burbelo PD (Sep 2002). "Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships". FEBS Lett. 528 (1–3): 27–34. doi:10.1016/S0014-5793(02)03331-8. PMID 12297274. S2CID 30443852.
↑ Worby CA, Dixon JE (Dec 2002). "Sorting out the cellular functions of sorting nexins". Nat Rev Mol Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558. S2CID 36361630.
1 2 "Entrez Gene: SNX26 sorting nexin 26".
↑ "O14559 · RHG33_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-24.

Xu Y, Seet LF, Hanson B, Hong W (2002). "The Phox homology (PX) domain, a new player in phosphoinositide signalling". Biochem. J. 360 (Pt 3): 513–30. doi:10.1042/0264-6021:3600513. PMC 1222253. PMID 11736640.
Dehal P, Predki P, Olsen AS, et al. (2001). "Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution". Science. 293 (5527): 104–11. doi:10.1126/science.1060310. PMID 11441184. S2CID 826987.
Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chiang SH, Hwang J, Legendre M, et al. (2003). "TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport". EMBO J. 22 (11): 2679–91. doi:10.1093/emboj/cdg262. PMC 156759. PMID 12773384.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19" (PDF). Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Liu H, Nakazawa T, Tezuka T, Yamamoto T (2006). "Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP". J. Biol. Chem. 281 (33): 23611–9. doi:10.1074/jbc.M511205200. PMID 16777849.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000004777 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036882 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12297274-5] Peck J, Douglas G IV, Wu CH, Burbelo PD (Sep 2002). "Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships". FEBS Lett. 528 (1–3): 27–34. doi:10.1016/S0014-5793(02)03331-8. PMID 12297274. S2CID 30443852.

[pmid12461558-6] Worby CA, Dixon JE (Dec 2002). "Sorting out the cellular functions of sorting nexins". Nat Rev Mol Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558. S2CID 36361630.

[entrez-7] 1 2 "Entrez Gene: SNX26 sorting nexin 26".

[8] "O14559 · RHG33_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-08-24.

v t e Sorting nexins
SNX-BAR	SNX1 SNX2 SNX4 SNX5 SNX6 SNX7 SNX8 SNX9 SNX18 SNX30 SNX32 SNX33
SNX-PX	SNX3 SNX10 SNX11 SNX12 SNX16 SNX20 SNX21 SNX22 SNX24 SNX29
SNX-Other	SNX13 SNX14 SNX15 SNX17 SNX19 SNX23 SNX25 SNX26 SNX27 SNX28 SNX31
Related articles	PX domain BAR domain Retromer

ARHGAP33

References

Further reading