Prior to 18th century
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- 218 BCE – Siege of Mutina (218 BC).
- 193 BCE – Battle of Mutina (193 BC) fought near town.
- 187 BCE – Via Aemilia built, passing through Mutina.
- 183 BCE – Mutina becomes "seat of a Roman colony."
- 78 BCE – Mutina besieged by forces of Pompey during the Roman civil wars.
- 44 BCE – War of Mutina begins.
- 43 BCE – Battle of Mutina fought in vicinity of town.
- 312 CE – Roman Catholic diocese of Modena established (approximate date).
- 7th C. CE – Citta Geminiana established near Modena.
- 872 – Leodoino becomes bishop.
- 1054 – Eriberto becomes bishop.
- 1099 – Modena Cathedral construction begins.
- 1175 – University of Modena founded.
- 1179 – Torre della Ghirlandina (Cathedral bell tower) set up.
- 1184 – Modena Cathedral consecrated.
- 1288 – Obizzo II d'Este in power; Este rule continues until 1796.
- 1325 – Modenese forces fight the Bolognese in the Battle of Zappolino.
- 1336 – House of Este in power.
- 1338 – University of Modena closes.
- 1348 – Black Death plague outbreak.
- 1452 – Duchy of Modena and Reggio established.
- 1474 – Printing press in operation.
- 1476 – San Pietro church construction begins.
- 1598 – Biblioteca Estense (library) relocated to Modena from Ferrara.
- 1634 – Ducal Palace of Modena construction begins.
- 1663 – Sant'Agostino church refurbished.
- 1671 – June: Earthquake.
- 1677 – Demetrio Degni starts publishing its weekly gazette named Modona, it lasted until 1701
- 1680 – Accademia dei Dissonanti founded.
- 1683 – University of Modena reestablished.
