MALAT1

MALAT1
Identifiants
Alias	MALAT1
IDs externes	OMIM: 607924 GeneCards: MALAT1
Position du gène (humain)
Chr.	Chromosome 11 humain
Fin	65,506,516 bp
Expression génique
	Fortement exprimé dans
	Médullaire rénale; ; ganglion trigéminal; ; cardia; ; corps calleux; ; pylore; ; vésicule séminale; ; tendon calcanéen; ; external globus pallidus; ; ganglion sensitif d’un nerf spinal; ; Pars compacta;
	n/a
	Plus de données d'expression de référence
	n/a
Orthologues
	378938
	n/a
	ENSG00000251562
	n/a
	n; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
Voir/Editer Humain

Le MALAT1 (pour « metastasis associated lung adenocarcinoma transcript 1 ») est un ARN long non codant. Son gène est MALAT1 situé sur le chromosome 11 humain.

Rôle

Il est exprimé particulièrement au niveau des poumons et du pancréas.

Dans les cancers, il intervient dans la migration cellulaire et l'invasion des tissus sains.

Au niveau vasculaire, il favorise le développement des cellules endothéliales, des cellules musculaires lisses et de la vascularisation. Chez le diabétique, il intervient ainsi dans la néovascularisation.

Au niveau moléculaire, il interagit avec la voie du P38-MAPK. Il inhibe l'expression du TNF-alpha et de l'interleukine 6 en empêchant la fixation du NF-κB sur l'ADN. Il favorise certains types d'épissage en jouant sur la phosphorylation de certains facteurs. Il cible également plusieurs micro-ARNs, dont le 506, le 1, le 200, 145 et le 206, ce qui favorise la prolifération de certains cancers. De même, son interaction avec le miR-101b régule l'expression du RAC1, favorisant la fibrose hépatique.

En médecine

Il est exprimé par de nombreux cancers dont certains cancers bronchiques non à petites cellules et sa présence semble corrélée avec un risque plus important de métastases.

Il serait protecteur quant à la formation de l'athérome, inhibant la prolifération des cellules hématopoïétiques.

Notes et références

1 2 3 GRCh38: Ensembl release 89: ENSG00000251562 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
1 2 Ji P, Diederichs S, Wang W, Böing S et al. MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer, Oncogene, 2003;22:8031–8041
↑ Dhamija S, Diederichs S, From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis, Int J Cancer, 2016;139:269–280
↑ Michalik KM, You X, Manavski Y et al. Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth, Circ Res, 2014;114:1389–1397
↑ Brock M, Schuoler C, Leuenberger C et al. Analysis of hypoxia-induced noncoding RNAs reveals metastasis-associated lung adenocarcinoma transcript 1 as an important regulator of vascular smooth muscle cell proliferation, Exp Biol Med (Maywood), 2017;242:487–496
1 2 Liu JY, Yao J, Li XM et al. Pathogenic role of lncRNA-MALAT1 in endothelial cell dysfunction in diabetes mellitus, Cell Death Dis, 2014; 5:e1506
↑ Zhao G, Su Z, Song D, Mao Y, Mao X, The long noncoding RNA MALAT1 regulates the lipopolysaccharide-induced inflammatory response through its interaction with NF-κB, FEBS Lett, 2016; 590:2884–2895
↑ Tripathi V, Ellis JD, Shen Z et al. The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation, Mol Cell, 2010;39:925–938
↑ Lei R, Xue M, Zhang L, Lin Z, Long noncoding RNA MALAT1-regulated microRNA 506 modulates ovarian cancer growth by targeting iASPP, Onco Targets Ther, 2017;10:35–46
↑ Chou J, Wang B, Zheng T et al. MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42, Biochem Biophys Res Commun, 2016;472:262–269
↑ Xiao H, Tang K, Liu P et al. [=5357&path[]=17299 LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200s in clear cell kidney carcinoma], Oncotarget, 2015;6:38005–38015
↑ Lu H, He Y, Lin L, Qi Z, Ma L, Li L, Su Y, Long non-coding RNA MALAT1 modulates radiosensitivity of HR-HPV+ cervical cancer via sponging miR-145, Tumour Biol, 2016;37:1683–1691
↑ Wang SH, Zhang WJ, Wu XC et al. [=9347 Long non-coding RNA Malat1 promotes gallbladder cancer development by acting as a molecular sponge to regulate miR-206], Oncotarget, 2016;7:37857–37867
↑ Yu F, Lu Z, Cai J et al. MALAT1 functions as a competing endogenous RNA to mediate Rac1 expression by sequestering miR-101b in liver fibrosis, Cell Cycle, 2015;14:3885–3896
↑ Cremer S, Michalik KM , Fischer A et al. Hematopoietic deficiency of the long noncoding RNA MALAT1 promotes atherosclerosis and plaque inflammation, Circulation, 2018;139:1320–1334

Portail de la biologie cellulaire et moléculaire

Portail de la médecine

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000251562 - Ensembl, May 2017

[2] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[Ji_2003-3] 1 2 Ji P, Diederichs S, Wang W, Böing S et al. MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer, Oncogene, 2003;22:8031–8041

[Dhamija_2016-4] Dhamija S, Diederichs S, From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis, Int J Cancer, 2016;139:269–280

[Michalik_2014-5] Michalik KM, You X, Manavski Y et al. Long noncoding RNA MALAT1 regulates endothelial cell function and vessel growth, Circ Res, 2014;114:1389–1397

[Brock_2017-6] Brock M, Schuoler C, Leuenberger C et al. Analysis of hypoxia-induced noncoding RNAs reveals metastasis-associated lung adenocarcinoma transcript 1 as an important regulator of vascular smooth muscle cell proliferation, Exp Biol Med (Maywood), 2017;242:487–496

[Liu_2014-7] 1 2 Liu JY, Yao J, Li XM et al. Pathogenic role of lncRNA-MALAT1 in endothelial cell dysfunction in diabetes mellitus, Cell Death Dis, 2014; 5:e1506

[Zhao_2016-8] Zhao G, Su Z, Song D, Mao Y, Mao X, The long noncoding RNA MALAT1 regulates the lipopolysaccharide-induced inflammatory response through its interaction with NF-κB, FEBS Lett, 2016; 590:2884–2895

[Tripathi_2010-9] Tripathi V, Ellis JD, Shen Z et al. The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation, Mol Cell, 2010;39:925–938

[Lei_2017-10] Lei R, Xue M, Zhang L, Lin Z, Long noncoding RNA MALAT1-regulated microRNA 506 modulates ovarian cancer growth by targeting iASPP, Onco Targets Ther, 2017;10:35–46

[Chou_2016-11] Chou J, Wang B, Zheng T et al. MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42, Biochem Biophys Res Commun, 2016;472:262–269

[Xiao_2015-12] Xiao H, Tang K, Liu P et al. [=5357&path[]=17299 LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200s in clear cell kidney carcinoma], Oncotarget, 2015;6:38005–38015

[Lu_2016-13] Lu H, He Y, Lin L, Qi Z, Ma L, Li L, Su Y, Long non-coding RNA MALAT1 modulates radiosensitivity of HR-HPV+ cervical cancer via sponging miR-145, Tumour Biol, 2016;37:1683–1691

[Wang_2016-14] Wang SH, Zhang WJ, Wu XC et al. [=9347 Long non-coding RNA Malat1 promotes gallbladder cancer development by acting as a molecular sponge to regulate miR-206], Oncotarget, 2016;7:37857–37867

[Yu_2015-15] Yu F, Lu Z, Cai J et al. MALAT1 functions as a competing endogenous RNA to mediate Rac1 expression by sequestering miR-101b in liver fibrosis, Cell Cycle, 2015;14:3885–3896

[Cremer_2018-16] Cremer S, Michalik KM , Fischer A et al. Hematopoietic deficiency of the long noncoding RNA MALAT1 promotes atherosclerosis and plaque inflammation, Circulation, 2018;139:1320–1334