Edrecolomab

Edrecolomab
Caratteristiche generali
Numero CAS	156586-89-9
Codice ATC	L01XC01
DrugBank	DBDB13375
Indicazioni di sicurezza
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Il Edrecolomab' o MAb17-1A nome commerciale Panorex, è un anticorpo monoclonale di topo, che viene utilizzato per il trattamento del tumore del colon retto ed altre forme tumorali con metastasi ai linfonodi.

Il farmaco agisce sull'antigene: EpCAM (17-1A) che è iper-espresso sulle cellule epiteliali di vari tipi di carcinoma.

Note

↑ Riethmüller G, Schneider-Gädicke E, Schlimok G et al. Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma. German Cancer Aid 17-1A Study Group. Lancet. 1994;343(8907):1177-83. PMID 7909866
↑ Fields AL, Keller AM, Schwartzberg L et al. Edrecolomab (17-1A antibody) in combination with 5-fluorouracil based chemotherapy in the adjuvant treatment of stage III colon cancer: results of a randomised North American phase III study (abstract). Proc Am Soc Clin Oncol. 2002;21:128a.
↑ Punt CJ, Nagy A, Douillard JY et al. Edrecolomab alone or in combination with fluorouracil and folinic acid in the adjuvant treatment of stage III colon cancer: a randomised study. Lancet. 2002;360(9334):671-7. DOI: 10.1016/S0140-6736(02)09836-7 PMID 12241873
↑ Colacchio TA, Niedzwicki D, Compton C, et al. Phase III trial of adjuvant immunotherapy with MoAb 17-1A following resection for stage II adenocarcinoma of the colon (CALGB 9581). Proc Am Soc Clin Oncol. 2004;23:251a.

Bibliografia

Frank Ashall, Le grandi scoperte scientifiche, Armando Editore, 1999, pp. 245–, ISBN 978-88-7144-949-4.
Abul K. Abbas, Andrew H. Lichtman e Shiv Pillai, Immunologia cellulare e molecolare, Elsevier srl, 2010, pp. 79–, ISBN 978-88-214-3176-0.
accessdate Abul K. Abbas e Andrew H. Lichtman, Le basi dell'immunologia, Elsevier srl, 2006, pp. 70–, ISBN 978-88-85675-85-8.
accessdate Humphrey P. Rang, M. Maureen Dale e James M. Ritter, Farmacologia, Elsevier srl, 2008, pp. 778–, ISBN 978-88-214-3023-7.
Enzo Fagiolo, Immunoematologia, Mediserve s.r.l., 2007, pp. 16–, ISBN 978-88-8204-135-9.
Paolo Larizza, Trattato di medicina interna, PICCIN, 2005, pp. 909–, ISBN 978-88-299-1721-1.
Angelo Sghirlanzoni, Terapia Delle Malattie Neurologiche, Springer, 3 aprile 2010, pp. 113–, ISBN 978-88-470-1119-9.
Thomas C. King, Patologia, Elsevier srl, 2008, pp. 156–, ISBN 978-88-214-3019-0.
(EN) whqlibdoc.who.int (archiviato dall'url originale il 16 ottobre 2009).
(EN) Marie A. Simmons, Monoclonal antibodies: new research, Nova Publishers, 2005, ISBN 978-1-59454-247-3.
(EN) Zhiqiang An, Therapeutic Monoclonal Antibodies: From Bench to Clinic, John Wiley and Sons, 8 settembre 2009, ISBN 978-0-470-11791-0.
(EN) James W. Goding, Monoclonal antibodies: principles and practice : production and application of monoclonal antibodies in cell biology, biochemistry and immunology, Academic Press, 1996, ISBN 978-0-12-287023-1.
(EN) Steve Shire, Current Trends in Monoclonal Antibody Development and Manufacturing, Springer, aprile 2009, ISBN 978-0-387-76642-3.

Edrecolomab

(EN) Robert O. Dillman, Principles of Cancer Biotherapy, Springer, luglio 2009, pp. 376–, ISBN 978-90-481-2277-6.
(EN) Vincent T. DeVita, Theodore S. Lawrence, Steven A. Rosenberg, Robert A. Weinberg, Ronald A. DePinho, DeVita, Hellman, and Rosenberg's cancer: principles & practice of oncology, Lippincott Williams & Wilkins, 1º aprile 2008, pp. 1256–, ISBN 978-0-7817-7207-5.

(EN) Olivier Gires e Barbara Seliger, Tumor-Associated Antigens: Identification, Characterization, and Clinical Applications, Wiley-VCH, 2009, pp. 190–, ISBN 978-3-527-32084-4.

Voci correlate

Portale Chimica

Portale Medicina

[Lancet1994-1] Riethmüller G, Schneider-Gädicke E, Schlimok G et al. Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes' C colorectal carcinoma. German Cancer Aid 17-1A Study Group. Lancet. 1994;343(8907):1177-83. PMID 7909866

[Proc2002-2] Fields AL, Keller AM, Schwartzberg L et al. Edrecolomab (17-1A antibody) in combination with 5-fluorouracil based chemotherapy in the adjuvant treatment of stage III colon cancer: results of a randomised North American phase III study (abstract). Proc Am Soc Clin Oncol. 2002;21:128a.

[3] Punt CJ, Nagy A, Douillard JY et al. Edrecolomab alone or in combination with fluorouracil and folinic acid in the adjuvant treatment of stage III colon cancer: a randomised study. Lancet. 2002;360(9334):671-7. DOI: 10.1016/S0140-6736(02)09836-7 PMID 12241873

[stageII-4] Colacchio TA, Niedzwicki D, Compton C, et al. Phase III trial of adjuvant immunotherapy with MoAb 17-1A following resection for stage II adenocarcinoma of the colon (CALGB 9581). Proc Am Soc Clin Oncol. 2004;23:251a.