Normetanefrina
| Normetanefrina | |
|---|---|
 | |
| Nome IUPAC | |
| 4-(2-amino-1-idrossi-etile)- 2-metossi-fenolo | |
| Caratteristiche generali | |
| Formula bruta o molecolare | C9H13NO3 |
| Massa molecolare (u) | 183.204 |
| Numero CAS | |
| PubChem | 1237 |
| SMILES | COC1=C(C=CC(=C1)C(CN)O)O |
| Indicazioni di sicurezza | |
La normetanefrina 4-(2-amino-1-idrossi-etile)- 2-metossi-fenolo è un metabolita intermedio del metabolismo delle catecolamine, si viene a formare in seguito all'azione dell'enzima catecolo O-metiltransferasi sulla noradrenalina.
Sia la normetanefrina che la metanefrina vengono espulse nelle urine ed il loro dosaggio le rende un marcatore per i tumori secernenti catecolamine, come il feocromocitoma. Assieme alla metanefrina rappresenta il 20-40% dei cataboliti urinari provenienti dal metabolismo delle catecolamine.
Marcatore tumorale
I valori normali di metanefrina e normetanefrina, prendendo a riferimento le urine delle 24h sono compresi fra i 310-510 µg/24, un loro innalzamento viene associato all'insorgenza di feocromocitomi, sono possibili falsi positivi in quanto i valori di tali molecole nel sangue possono innalzarsi anche a seguito di terapie con IMAO, catecolamine, L-Dopa, beta-bloccanti e nei soggetti affetti da etilismo cronico.
Note
- ↑ D. Andreani,G. Menzinger, D. Andreani; (1984) "Trattato di diagnostica funzionale endocrinologica" ISBN 88-299-0196-2
- ↑ M. Mannelli1, T. Ercolino1, L. Becherini1, G. Bernini2, L. Simi1, G. Parenti1; Ligand Assay (2006); "Diagnosi genetica e biochimica del ferocromocitoma"
Bibliografia
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