SPINK1

Inibitore della secrezione pancreatica della tripsina
Gene
HUGO	SPINK1; PCTT; PSTI; Spink3; TATI
Entrez	6690
Proteina
OMIM	167790
UniProt	P00995
	Modifica dati su Wikidata · Manuale

L'inibitore della secrezione pancreatica della tripsina è una proteina che nell'uomo viene codificata dal gene SPINK1. Fa parte degli inibitori della attività endopeptidasi tipo-serina. Viene iper-espresso nel carcinoma prostatico.

Note

↑ Entrez Gene: SPINK1 serine peptidase inhibitor, Kazal type 1, su ncbi.nlm.nih.gov.
↑ Tomlins SA, Rhodes DR, Yu J, et al., The role of SPINK1 in ETS rearrangement-negative prostate cancers, in Cancer Cell, vol. 13, n. 6, giugno 2008, pp. 519–28, DOI:10.1016/j.ccr.2008.04.016, PMC 2732022, PMID 18538735.

Bibliografia

Marchbank T, Freeman TC, Playford RJ, Human pancreatic secretory trypsin inhibitor. Distribution, actions and possible role in mucosal integrity and repair., in Digestion, vol. 59, n. 3, 1998, pp. 167–74, PMID 9643675.
Pfützer RH, Whitcomb DC, SPINK1 mutations are associated with multiple phenotypes., in Pancreatology, vol. 1, n. 5, 2002, pp. 457–60, DOI:10.1159/000055847, PMID 12120224.
Schneider A, Serine protease inhibitor kazal type 1 mutations and pancreatitis., in Clin. Lab. Med., vol. 25, n. 1, 2005, pp. 61–78, DOI:10.1016/j.cll.2004.12.005, PMID 15749232.
Cohn JA, Mitchell RM, Jowell PS, The impact of cystic fibrosis and PSTI/SPINK1 gene mutations on susceptibility to chronic pancreatitis., in Clin. Lab. Med., vol. 25, n. 1, 2005, pp. 79–100, DOI:10.1016/j.cll.2004.12.007, PMID 15749233.
Kandula L, Whitcomb DC, Lowe ME, Genetic issues in pediatric pancreatitis., in Current gastroenterology reports, vol. 8, n. 3, 2006, pp. 248–53, DOI:10.1007/s11894-006-0083-8, PMID 16764792.
Bartelt DC, Shapanka R, Greene LJ, The primary structure of the human pancreatic secretory trypsin inhibitor. Amino acid sequence of the reduced S-aminoethylated protein., in Arch. Biochem. Biophys., vol. 179, n. 1, 1977, pp. 189–99, DOI:10.1016/0003-9861(77)90103-5, PMID 843082.
Hecht HJ, Szardenings M, Collins J, Schomburg D, Three-dimensional structure of a recombinant variant of human pancreatic secretory trypsin inhibitor (Kazal type)., in J. Mol. Biol., vol. 225, n. 4, 1992, pp. 1095–103, DOI:10.1016/0022-2836(92)90107-U, PMID 1613792.
Hecht HJ, Szardenings M, Collins J, Schomburg D, Three-dimensional structure of the complexes between bovine chymotrypsinogen A and two recombinant variants of human pancreatic secretory trypsin inhibitor (Kazal-type)., in J. Mol. Biol., vol. 220, n. 3, 1991, pp. 711–22, DOI:10.1016/0022-2836(91)90112-J, PMID 1870127.
Freeman TC, Davies R, Calam J, Interactions of pancreatic secretory trypsin inhibitor in small intestinal juice: its hydrolysis and protection by intraluminal factors., in Clin. Chim. Acta, vol. 195, n. 1-2, 1991, pp. 27–39, DOI:10.1016/0009-8981(90)90191-T, PMID 2093478.
Kido H, Yokogoshi Y, Katunuma N, A low-molecular-mass Kazal-type protease inhibitor isolated from rat hepatocytes is identical to rat pancreatic secretory trypsin inhibitor II. Purification and amino acid sequence., in Eur. J. Biochem., vol. 188, n. 3, 1990, pp. 501–6, DOI:10.1111/j.1432-1033.1990.tb15428.x, PMID 2110056.
Tomita N, Horii A, Yamamoto T, et al., Expression of pancreatic secretory trypsin inhibitor gene in neoplastic tissues., in FEBS Lett., vol. 225, n. 1-2, 1988, pp. 113–9, DOI:10.1016/0014-5793(87)81141-9, PMID 2961612.
Horii A, Kobayashi T, Tomita N, et al., Primary structure of human pancreatic secretory trypsin inhibitor (PSTI) gene., in Biochem. Biophys. Res. Commun., vol. 149, n. 2, 1988, pp. 635–41, DOI:10.1016/0006-291X(87)90415-3, PMID 3501289.
Yamamoto T, Nakamura Y, Nishide J, et al., Molecular cloning and nucleotide sequence of human pancreatic secretory trypsin inhibitor (PSTI) cDNA., in Biochem. Biophys. Res. Commun., vol. 132, n. 2, 1985, pp. 605–12, DOI:10.1016/0006-291X(85)91176-3, PMID 3877508.
Huhtala ML, Pesonen K, Kalkkinen N, Stenman UH, Purification and characterization of a tumor-associated trypsin inhibitor from the urine of a patient with ovarian cancer., in J. Biol. Chem., vol. 257, n. 22, 1983, pp. 13713–6, PMID 7142173.
Klaus W, Schomburg D, Solution structure of a variant of human pancreatic secretory trypsin inhibitor determined by nuclear magnetic resonance spectroscopy., in J. Mol. Biol., vol. 229, n. 3, 1993, pp. 695–706, DOI:10.1006/jmbi.1993.1073, PMID 8433367.
Chen JM, Mercier B, Audrezet MP, Ferec C, Mutational analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene in hereditary and sporadic chronic pancreatitis., in J. Med. Genet., vol. 37, n. 1, 2000, pp. 67–9, DOI:10.1136/jmg.37.1.67, PMC 1734438, PMID 10691414.
Witt H, Luck W, Hennies HC, et al., Mutations in the gene encoding the serine protease inhibitor, Kazal type 1 are associated with chronic pancreatitis., in Nat. Genet., vol. 25, n. 2, 2000, pp. 213–6, DOI:10.1038/76088, PMID 10835640.
Pfützer RH, Barmada MM, Brunskill AP, et al., SPINK1/PSTI polymorphisms act as disease modifiers in familial and idiopathic chronic pancreatitis., in Gastroenterology, vol. 119, n. 3, 2000, pp. 615–23, DOI:10.1053/gast.2000.18017, PMID 10982753.
Kaneko K, Nagasaki Y, Furukawa T, et al., Analysis of the human pancreatic secretory trypsin inhibitor (PSTI) gene mutations in Japanese patients with chronic pancreatitis., in J. Hum. Genet., vol. 46, n. 5, 2001, pp. 293–7, DOI:10.1007/s100380170082, PMID 11355022.

Portale Biologia

Portale Medicina

[entrez-1] Entrez Gene: SPINK1 serine peptidase inhibitor, Kazal type 1, su ncbi.nlm.nih.gov.

[pmid18538735-2] Tomlins SA, Rhodes DR, Yu J, et al., The role of SPINK1 in ETS rearrangement-negative prostate cancers, in Cancer Cell, vol. 13, n. 6, giugno 2008, pp. 519–28, DOI:10.1016/j.ccr.2008.04.016, PMC 2732022, PMID 18538735.

Inibitore della secrezione pancreatica della tripsina

Gene
HUGO	SPINK1; PCTT; PSTI; Spink3; TATI
Entrez	6690
Proteina
OMIM	167790
UniProt	P00995
Modifica dati su Wikidata · Manuale