2CD-2,5-DiEtO

2CD-2,5-DiEtO
Clinical data
Other names2CD-DiEtO; 2CD-Di-EtO; 2CD-DIETO; 2CD-DI-ETO; 2,5-Diethoxy-4-methylphenethylamine; 4-Methyl-2,5-diethoxyphenethylamine
Routes of
administration		Oral
Drug classPsychoactive drug
ATC code
  • None
Pharmacokinetic data
Duration of action4 hours
Identifiers
  • 2-(2,5-diethoxy-4-methylphenyl)ethan-1-amine
Chemical and physical data
FormulaC13H21NO2
Molar mass223.316 g·mol−1
3D model (JSmol)
  • CCOC1=CC(CCN)=C(OCC)C=C1C
  • InChI=1S/C13H21NO2/c1-4-15-12-9-11(6-7-14)13(16-5-2)8-10(12)3/h8-9H,4-7,14H2,1-3H3
  • Key:ALVWRNQBQUMSMA-UHFFFAOYSA-N

2CD-2,5-DiEtO, also known as 2,5-diethoxy-4-methylphenethylamine, is a psychoactive drug of the phenethylamine, 2C, and TWEETIO families related to the psychedelic drug 2C-D. It is the derivative of 2C-D in which the methoxy groups at the 2 and 5 positions have been replaced with ethoxy groups.

According to Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, 2CD-2,5-DiEtO's dose is greater than 55 mg orally and its duration is 4 hours. 2CD-2,5-DiEtO has been described as producing mild effects that were no greater than a "plus-one" on the Shulgin Rating Scale. No specific effects have been described and higher doses were not tested.

The chemical synthesis of 2CD-2,5-DiEtO has been described.

2CD-2,5-DiEtO was first described in the literature by Shulgin in PiHKAL in 1991. It was developed and tested by Darrell Lemaire, with publication via personal communication with Shulgin. The drug is a controlled substance in Canada under phenethylamine blanket-ban language.

See also

References

  1. 1 2 3 4 5 6 7 8 9 Shulgin A, Shulgin A (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. "The 2,5-di-EtO homologue of 2C-D is 2,5-diethoxy-4-methylphenethylamine, or 2CD-2,5-DIETO. The benzaldehyde (2,5-diethoxy-4-tolualdehyde) had a melting point of 102–103 °C, the nitrostyrene intermediate a melting point of 108–109 °C, and the final hydrochloride salt a melting point of 251–252 °C. At a level of 55 milligrams, a plus one was reached, and what effects there were, were gone after four hours."
  2. 1 2 3 4 5 6 7 8 Shulgin AT (2003). "Basic Pharmacology and Effects". In Laing RR (ed.). Hallucinogens: A Forensic Drug Handbook. Forensic Drug Handbook Series. Elsevier Science. pp. 67–137. ISBN 978-0-12-433951-4. Archived from the original on 13 July 2025.
  3. 1 2 3 4 5 6 7 Trachsel D, Lehmann D, Enzensperger C (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag. ISBN 978-3-03788-700-4. OCLC 858805226. Archived from the original on 21 August 2025.
  4. ↑ "Erowid Darrell Lemaire Vault". erowid.org. Retrieved 14 November 2025.
  5. ↑ Morris H (7 December 2016). "The Lazy Lizard School of Hedonism". Hamilton's Pharmacopeia. Season 1. Episode 6. Vice Media. Viceland.
  6. ↑ Nez H, Lemaire D (2010). "Notes About Psychoactive Compounds" (PDF). In Targ R, Radin D (eds.). Radiant Minds: Scientists Explore the Dimensions of Consciousness. Millay. pp. 201–207. ISBN 978-0-615-29633-3.
  7. ↑ Nez H, Lemaire D (Lazar) (1990). Certain Exotic Transmitters as Smart Pills or Compounds that Increase the Capacity for Mental Work in Humans: A Story About LAZAR as Told by Hosteen Nez (2nd ed.). Archived from the original (PDF) on 9 July 2001.
  8. ↑ "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.