2CT2-2,5-DiEtO

2CT2-2,5-DiEtO
Clinical data
Other names2CT2-DiEtO; 2CT2-Di-EtO; 2CT2-DIETO; 2CT2-DI-ETO; 2,5-Diethoxy-4-ethylthiophenethylamine; 4-Ethylthio-2,5-diethoxyphenethylamine
Routes of
administration		Oral
Drug classPsychoactive drug
ATC code
  • None
Pharmacokinetic data
Duration of action~9 hours
Identifiers
  • 2-[2,5-diethoxy-4-(ethylsulfanyl)phenyl]ethan-1-amine
PubChem CID
Chemical and physical data
FormulaC14H23NO2S
Molar mass269.40 g·mol−1
3D model (JSmol)
  • CCOC1=CC(SCC)=C(OCC)C=C1CCN
  • InChI=1S/C14H23NO2S/c1-4-16-12-10-14(18-6-3)13(17-5-2)9-11(12)7-8-15/h9-10H,4-8,15H2,1-3H3
  • Key:HDKGMXYAXURMGE-UHFFFAOYSA-N

2CT2-2,5-DiEtO, also known as 2,5-diethoxy-4-ethylthiophenethylamine, is a psychoactive drug of the phenethylamine, 2C, and TWEETIO families related to the psychedelic drug 2C-T-2. It is the derivative of 2C-T-2 in which the methoxy groups at the 2 and 5 positions have been replaced with ethoxy groups.

According to Alexander Shulgin in his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, 2CT2-2,5-DiEtO's dose is 10 to 50 mg orally and its duration is approximately 9 hours. The effects of 2CT2-2,5-DiEtO have been reported to include initial nervousness and edginess followed by energy and high attentiveness, few if any sensory alterations, and no next-day hangover. Higher doses across the range of 10 to 50 mg orally were not particularly different in terms of intensity, but were progressively longer in duration. At 50 mg orally, the duration was around 9 hours.

The chemical synthesis of 2CT2-2,5-DiEtO has been described.

2CT2-2,5-DiEtO was first described in the literature by Shulgin in PiHKAL in 1991. It was developed and tested by Darrell Lemaire, with publication via personal communication with Shulgin. The drug is a controlled substance in Canada under phenethylamine blanket-ban language.

See also

References

  1. 1 2 3 4 5 6 7 8 9 10 Shulgin A, Shulgin A (September 1991). PiHKAL: A Chemical Love Story. Berkeley, California: Transform Press. ISBN 0-9630096-0-5. OCLC 25627628. "The 2,5-DiEtO-homologue of 2C-T-2 is 2,5-diethoxy-4-ethylthiophenethylamine, or 2CT2-2,5DIETO. The benzaldehyde, 2,5-diethoxy-4-(ethylthio)benzaldehyde, had a melting point of 84–85 °C, the nitrostyrene intermediate a melting point of 123–124 °C, and the final hydrochloride a melting point of 220–221 °C. Levels that were evaluated from 10 to 50 milligrams were not particularly different in intensity, but were progressively longer in duration. At 50 milligrams there was a nervousness and edginess during the early part of the experience, but for the next several hours there was evident both energy and high attentiveness. There were few if any sensory alterations. There were no negatives on the following day. The duration was perhaps nine hours."
  2. 1 2 3 4 5 6 7 8 9 Shulgin AT (2003). "Basic Pharmacology and Effects". In Laing RR (ed.). Hallucinogens: A Forensic Drug Handbook. Forensic Drug Handbook Series. Elsevier Science. pp. 67–137. ISBN 978-0-12-433951-4. Archived from the original on 13 July 2025.
  3. 1 2 3 4 5 6 7 8 Trachsel D, Lehmann D, Enzensperger C (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag. ISBN 978-3-03788-700-4. OCLC 858805226. Archived from the original on 21 August 2025.
  4. ↑ "Erowid Darrell Lemaire Vault". erowid.org. Retrieved 14 November 2025.
  5. ↑ Morris H (7 December 2016). "The Lazy Lizard School of Hedonism". Hamilton's Pharmacopeia. Season 1. Episode 6. Vice Media. Viceland.
  6. ↑ Nez H, Lemaire D (2010). "Notes About Psychoactive Compounds" (PDF). In Targ R, Radin D (eds.). Radiant Minds: Scientists Explore the Dimensions of Consciousness. Millay. pp. 201–207. ISBN 978-0-615-29633-3.
  7. ↑ Nez H, Lemaire D (Lazar) (1990). Certain Exotic Transmitters as Smart Pills or Compounds that Increase the Capacity for Mental Work in Humans: A Story About LAZAR as Told by Hosteen Nez (2nd ed.). Archived from the original (PDF) on 9 July 2001.
  8. ↑ "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.