Brinase

Brinase
Clinical data
ATC code	B01AD06 (WHO)
Identifiers
CAS Number	9000-99-1^Y
DrugBank	DB13199^Y
ChemSpider	none
UNII	Z3GVO2327F
KEGG	D03157
^NY (what is this?) (verify)

Brinase (or brinolase) is a fibrinolytic enzyme, and a thrombolytic drug.

It is derived from Aspergillus oryzae.

See also

Aspergillus oryzae

References

↑ Frisch EP (July 1972). "Clinical experience with brinase". Journal of Clinical Pathology. 25 (7): 654–5. doi:10.1136/jcp.25.7.654. PMC 477472. PMID 5070274.
↑ Roschlau WH (July 1972). "Thrombolytic properties and side effects of brinase (fibrinolytic enzyme from Aspergillus oryzae) in the dog". Journal of Clinical Pathology. 25 (7): 635–6. doi:10.1136/jcp.25.7.635. PMC 477457. PMID 5070267.

External links

Brinolase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)

Antiplatelet drugs

Glycoprotein IIb/IIIa inhibitors	Abciximab Eptifibatide Orbofiban Roxifiban Sibrafiban^§ Tirofiban
ADP receptor/P2Y₁₂ inhibitors	Thienopyridines Clopidogrel Prasugrel Ticlopidine Nucleotide/nucleoside analogs Cangrelor Elinogrel Ticagrelor
Prostaglandin analogue (PGI2)	Beraprost Iloprost Prostacyclin Treprostinil
COX inhibitors	Acetylsalicylic acid/Aspirin^# Aloxiprin Carbasalate calcium Indobufen Triflusal
Thromboxane inhibitors	Thromboxane synthase inhibitors Dipyridamole (+ aspirin) Picotamide Terbogrel Receptor antagonists Terbogrel Terutroban^§
Phosphodiesterase inhibitors	Cilostazol Dipyridamole Triflusal
Other	Cloricromen Ditazole Vorapaxar

Vitamin K antagonists
(inhibit II, VII, IX, X)

Factor Xa inhibitors
(with some II inhibition)

Heparin group/ glycosaminoglycans/ (bind antithrombin)	Low-molecular-weight heparin Bemiparin Certoparin Dalteparin Enoxaparin Nadroparin Parnaparin Reviparin Tinzaparin Oligosaccharides Fondaparinux Idraparinux^§ Heparinoids Danaparoid Dermatan sulfate Sulodexide
Direct Xa inhibitors ("xabans")	Apixaban Betrixaban Darexaban^§ Edoxaban Otamixaban^§ Rivaroxaban

Direct thrombin (IIa) inhibitors

Bivalent: Hirudin
- Bivalirudin
- Desirudin
- Lepirudin^‡
Univalent: Argatroban
Dabigatran
Efegatran
Inogatran^§
Melagatran^‡
Ximelagatran^‡

Other

Thrombolytic drugs/
fibrinolytics

Plasminogen activators: r-tPA
- Alteplase^#
- Reteplase
- Tenecteplase
- Desmoteplase^†
UPA
- Saruplase
- Urokinase
Anistreplase
Monteplase
Streptokinase^#
Other: Ancrod^‡
Brinase
Caplacizumab
Fibrinolysin

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

Hydrolase: proteases (EC 3.4)

3.4.11-19: Exopeptidase

3.4.11	Aminopeptidase Alanine Arginyl Aspartyl Cystinyl Leucyl Glutamyl Methionyl 1 2 O
3.4.13	Dipeptidase 1 2 3
3.4.14	Dipeptidyl peptidase Cathepsin C Dipeptidyl peptidase-4 Tripeptidyl peptidase Tripeptidyl peptidase I Tripeptidyl peptidase II
3.4.15	Angiotensin-converting enzyme
3.4.16	Serine type carboxypeptidases: Cathepsin A DD-Transpeptidase
3.4.17	Metalloexopeptidases Carboxypeptidase A A1 A2 B C E Glutamate II
Other/ungrouped	Metalloexopeptidase

3.4.21-25: Endopeptidase

Other/ungrouped: Amyloid-beta precursor protein secretase

3.4.99: Unknown

Staphylokinase

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