| abnormal dauer formation protein 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | daf-1 | ||||||
| Entrez | 176829 | ||||||
| Orthologs | NCBI: entry; OMA: entry | ||||||
| UniProt | P20792 | ||||||
| Other data | |||||||
| Chromosome | IV: 0.13 - 0.14 Mb | ||||||
| |||||||
The DAF-1 gene encodes for a cell surface Enzyme-linked receptor of TGF-beta signaling pathway in the worm Caenorhabditis elegans. DAF-1 is one of the type I receptor of TGF-beta pathway. DAF-1 acts as a receptor protein serine/threonine kinase, is activated by type II receptor Daf-4 phosphorylation after the ligand Daf-7 binds to the receptor heterotetramer, and then phosphorylates Daf-8 or Daf-14, the SMAD proteins in C. elegans.