Daf-7

abnormal dauer formation protein 7
Identifiers
OrganismCaenorhabditis elegans
Symboldaf-7
Entrez175237
OrthologsNCBI: entry; OMA: entry
RefSeq (mRNA)NM_064864.5
RefSeq (Prot)NP_497265.1
UniProtP92172
Other data
ChromosomeIII: 0.81 - 0.81 Mb
Search for
StructuresSwiss-model
DomainsInterPro

The DAF-7 gene encodes for the ortholog of GDF11, a ligand of TGF-beta signaling pathway, in the worm Caenorhabditis elegans. When binds to the complex of type II receptor Daf-4 and type I receptor Daf-1, this receptor protein serine/threonine kinase will phosphorylation activate the Smad Protein Daf-8/14.

References

  1. ↑ Morita K, Shimizu M, Shibuya H, Ueno N (May 2001). "A DAF-1-binding protein BRA-1 is a negative regulator of DAF-7 TGF-beta signaling". Proceedings of the National Academy of Sciences of the United States of America. 98 (11): 6284–8. Bibcode:2001PNAS...98.6284M. doi:10.1073/pnas.111409798. PMC 33460. PMID 11353865.
  2. ↑ Krishna S, Maduzia LL, Padgett RW (January 1999). "Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans". Development. 126 (2): 251–60. doi:10.1242/dev.126.2.251. PMID 9847239. S2CID 2460114.