Daf-4

abnormal dauer formation protein 4
Identifiers
OrganismCaenorhabditis elegans
Symboldaf-4
Entrez175781
OrthologsNCBI: entry; OMA: entry
UniProtP50488
Other data
ChromosomeIII: 5.63 - 5.63 Mb
Search for
StructuresSwiss-model
DomainsInterPro

The DAF-4 gene encodes for the only type II receptor of TGF-beta signaling pathway in the worm Caenorhabditis elegans, with the ligands Daf-7 or Dbl-1. When binds to the ligand Daf-7, Daf-4 complexed with the type I receptor Daf-1, and activated the Smad Protein Daf-8/14. By contrast, when binds to Dbl-1, Daf-4 complexed with the Sma-6 type I receptor, and activated the Sma-2/3/4.

References

  1. ↑ Estevez, M; Attisano, L; Wrana, J; Albert, PS; Massagué, J; Riddle, DL (October 1993). "The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development". Nature. 365: 644–649. doi:10.1038/365644a0.
  2. ↑ Savage C, Das P, Finelli AL, Townsend SR, Sun CY, Baird SE, Padgett RW (January 1996). "Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components". Proceedings of the National Academy of Sciences of the United States of America. 93 (2): 790–4. Bibcode:1996PNAS...93..790S. doi:10.1073/pnas.93.2.790. PMC 40134. PMID 8570636.
  3. ↑ Krishna S, Maduzia LL, Padgett RW (January 1999). "Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans". Development. 126 (2): 251–60. doi:10.1242/dev.126.2.251. PMID 9847239. S2CID 2460114.