| abnormal dauer formation protein 4 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | daf-4 | ||||||
| Entrez | 175781 | ||||||
| Orthologs | NCBI: entry; OMA: entry | ||||||
| UniProt | P50488 | ||||||
| Other data | |||||||
| Chromosome | III: 5.63 - 5.63 Mb | ||||||
| |||||||
The DAF-4 gene encodes for the only type II receptor of TGF-beta signaling pathway in the worm Caenorhabditis elegans, with the ligands Daf-7 or Dbl-1. When binds to the ligand Daf-7, Daf-4 complexed with the type I receptor Daf-1, and activated the Smad Protein Daf-8/14. By contrast, when binds to Dbl-1, Daf-4 complexed with the Sma-6 type I receptor, and activated the Sma-2/3/4.