HLA-B49

major histocompatibility complex (human), class I, B49
Alleles B*4901, B*4902, B*4903
Structure (See HLA-B)
Symbol(s) HLA-B
EBI-HLA B*4901
B*4902
B*4903
Locus chr.6 6p21.31

HLA-B49 (B49) is an HLA-B serotype. B49 is a split antigen from the B21 broad antigen, the sister serotype B50. The serotype identifies the more common HLA-B*50 gene products. (For terminology help see: HLA-serotype tutorial)

Serotype

B49 and B21 serotype recognition of some more common HLA B*49 alleles
B*49B49 B21Sample
allele%%size (N)
49019413002

Allele distribution

HLA B*4901 frequencies
freq
ref.Population(%)
Portugal North8.7
Spain Basque Gipuzkoa Province6.1
Madeira5.9
Cameroon Yaounde5.4
Morocco Nador Metalsa (Berber)5.1
Kenya Nandi4.6
Sudanese4.3
Portugal South4.1
Tunisia Tunis4.0
India Jalpaiguri Toto3.8
Senegal Niokholo Mandenka3.7
Uganda Kampala3.7
Spain Eastern Andalusia3.5
Tunisia3.5
Georgia Tbilisi Kurds3.4
Spain Catalonia Girona3.4
Italy North (1)3.3
Cameroon Beti3.2
Israel Ashkenazi and Non Ashkenazi Jews3.2
Guinea Bissau3.1
France South East2.7
Israel Arab Druse2.5
Mali Bandiagara2.5
Jordan Amman2.4
Tunisia Ghannouch2.4
Georgia Tbilisi Georgians2.3
Saudi Arabia Guraiat and Hail2.2
Cameroon Bamileke1.9
Czech Republic1.9
Georgia Svaneti Svans1.9
Macedonia (4)1.9
Bulgaria1.8
Romanian1.6
Italy Bergamo1.1
Zambia Lusaka1.1
Belgium1.0
China North Han1.0
India Andhra Pradesh Golla1.0
Ireland Northern1.0
South African Natal Zulu1.0

References

  1. ↑ Hildebrand WH, Madrigal JA, Belich MP, et al. (1992). "Serologic cross-reactivities poorly reflect allelic relationships in the HLA-B12 and HLA-B21 groups. Dominant epitopes of the alpha 2 helix". J. Immunol. 149 (11): 3563–8. PMID 1385528.
  2. ↑ Marsh, S. G.; Albert, E. D.; Bodmer, W. F.; Bontrop, R. E.; Dupont, B.; Erlich, H. A.; Fernández-Viña, M.; Geraghty, D. E.; Holdsworth, R.; Hurley, C. K.; Lau, M.; Lee, K. W.; Mach, B.; Maiers, M.; Mayr, W. R.; Müller, C. R.; Parham, P.; Petersdorf, E. W.; Sasazuki, T.; Strominger, J. L.; Svejgaard, A.; Terasaki, P. I.; Tiercy, J. M.; Trowsdale, J. (2010). "Nomenclature for factors of the HLA system, 2010". Tissue Antigens. 75 (4): 291–455. doi:10.1111/j.1399-0039.2010.01466.x. PMC 2848993. PMID 20356336.
  3. ↑ derived from IMGT/HLA
  4. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 Middleton D, Menchaca L, Rood H, Komerofsky R (2003). "New allele frequency database". Tissue Antigens. 61 (5): 403–7. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.