PKD2L2

PKD2L2
Identifiers
Aliases	PKD2L2, TRPP5, polycystin 2 like 2, transient receptor potential cation channel
External IDs	OMIM: 604669; MGI: 1858231; GeneCards: PKD2L2
Gene location (Human)
Chr.	Chromosome 5 (human)
End	137,942,747 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	34,577,169 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; buccal mucosa cell; ; testicle; ; left testis; ; right testis; ; sperm; ; internal globus pallidus; ; gonad; ; muscle of thigh; ; Achilles tendon;
	Top expressed in
	zygote; ; primary oocyte; ; secondary oocyte; ; spermatocyte; ; spermatid; ; granulocyte; ; seminiferous tubule; ; egg cell; ; supraoptic nucleus; ; muscle of thigh;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding; calcium channel activity;
Cellular component	integral component of membrane; membrane;
Biological process	ion transport; detection of mechanical stimulus; calcium ion transmembrane transport; biological process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	27039
	53871
	ENSG00000078795
	ENSMUSG00000014503
	Q9NZM6
	Q9JLG4
	NM_001258448; NM_001258449; NM_001300921; NM_014386
	NM_001163004; NM_016927
	NP_001245377; NP_001245378; NP_001287850; NP_055201
	NP_001156476; NP_058623
	Wikidata
View/Edit Human	View/Edit Mouse

Polycystic kidney disease 2-like 2 protein (PKD2L2) also known as transient receptor potential polycystic 5 (TRPP5) is a protein that in humans is encoded by the PKD2L2 gene.

This protein is a member of the transient receptor potential channel family of proteins, and is a homolog of Polycystin 2 (PKD2).

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000078795 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014503 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Veldhuisen B, Spruit L, Dauwerse HG, Breuning MH, Peters DJ (December 1999). "Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2)". Eur. J. Hum. Genet. 7 (8): 860–72. doi:10.1038/sj.ejhg.5200383. PMID 10602361.

Li Q, Liu Y, Zhao W, Chen XZ (2002). "The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation". FEBS Lett. 516 (1–3): 270–8. Bibcode:2002FEBSL.516..270L. doi:10.1016/S0014-5793(02)02513-9. PMID 11959145. S2CID 1812119.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Stayner C, Zhou J (2001). "Polycystin channels and kidney disease". Trends Pharmacol. Sci. 22 (11): 543–6. doi:10.1016/S0165-6147(00)01832-0. PMID 11698076.
Guo L, Schreiber TH, Weremowicz S, et al. (2000). "Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization". Genomics. 64 (3): 241–51. doi:10.1006/geno.2000.6131. PMID 10756092.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000078795 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014503 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10602361-5] Veldhuisen B, Spruit L, Dauwerse HG, Breuning MH, Peters DJ (December 1999). "Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2)". Eur. J. Hum. Genet. 7 (8): 860–72. doi:10.1038/sj.ejhg.5200383. PMID 10602361.

PKD2L2

See also

References

Further reading