TRD (gene)

TRD
Identifiers
Aliases	TRD, TCRD, TCRDV1, TRD@, T cell receptor delta locus, T-cell receptor delta locus
External IDs	GeneCards: TRD
Orthologs
Databases	NCBI: entry
	6964
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	n; a
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	Wikidata
View/Edit Human

T cell receptor delta locus (symbol TRD), also known as TCRD or TRD@, is a protein that in humans is encoded by the TRD gene. It contributes the delta (δ) chain to the larger TCR protein (T-cell receptor).

References

↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: TRD@ T cell receptor delta locus".

Chien YH, Iwashima M, Kaplan KB, Elliott JF, Davis MM (1987). "A new T-cell receptor gene located within the alpha locus and expressed early in T-cell differentiation". Nature. 327 (6124): 677–82. Bibcode:1987Natur.327..677C. doi:10.1038/327677a0. PMID 2439914. S2CID 4327838.
Hayes SM, Shores EW, Love PE (February 2003). "An architectural perspective on signaling by the pre-, alphabeta and gammadelta T cell receptors". Immunological Reviews. 191: 28–37. doi:10.1034/j.1600-065X.2003.00011.x. PMID 12614349. S2CID 28556794.
Guglielmi P, Davi F, d'Auriol L, Bories JC, Dausset J, Bensussan A (August 1988). "Use of a variable alpha region to create a functional T-cell receptor delta chain". Proceedings of the National Academy of Sciences of the United States of America. 85 (15): 5634–8. Bibcode:1988PNAS...85.5634G. doi:10.1073/pnas.85.15.5634. PMC 281814. PMID 2456576.
Hochstenbach F, Brenner MB (August 1989). "T-cell receptor delta-chain can substitute for alpha to form a beta delta heterodimer". Nature. 340 (6234): 562–5. Bibcode:1989Natur.340..562H. doi:10.1038/340562a0. PMID 2528071. S2CID 29948685.
Dyer MJ (August 1989). "T-cell receptor delta/alpha rearrangements in lymphoid neoplasms". Blood. 74 (3): 1073–83. doi:10.1182/blood.V74.3.1073.1073. PMID 2546634.
Griesinger F, Greenberg JM, Kersey JH (August 1989). "T cell receptor gamma and delta rearrangements in hematologic malignancies. Relationship to lymphoid differentiation". The Journal of Clinical Investigation. 84 (2): 506–16. doi:10.1172/JCI114193. PMC 548910. PMID 2547833.
Loh EY, Lanier LL, Turck CW, Littman DR, Davis MM, Chien YH, Weiss A (1988). "Identification and sequence of a fourth human T cell antigen receptor chain". Nature. 330 (6148): 569–72. doi:10.1038/330569a0. PMID 2825032. S2CID 4362226.
Bartkowiak J, Kulczyck-Wojdala D, Blonski JZ, Robak T (2002). "Molecular diversity of gammadelta T cells in peripheral blood from patients with B-cell chronic lymphocytic leukaemia". Neoplasma. 49 (2): 86–90. PMID 12088111.
Oyoshi MK, Nagata H, Kimura N, Zhang Y, Demachi A, Hara T, Kanegane H, Matsuo Y, Yamaguchi T, Morio T, Hirano A, Shimizu N, Yamamoto K (May 2003). "Preferential expansion of Vgamma9-JgammaP/Vdelta2-Jdelta3 gammadelta T cells in nasal T-cell lymphoma and chronic active Epstein-Barr virus infection". The American Journal of Pathology. 162 (5): 1629–38. doi:10.1016/S0002-9440(10)64297-6. PMC 1851204. PMID 12707047.
Krejci O, Prouzova Z, Horvath O, Trka J, Hrusak O (July 2003). "Cutting edge: TCR delta gene is frequently rearranged in adult B lymphocytes". Journal of Immunology. 171 (2): 524–7. doi:10.4049/jimmunol.171.2.524. PMID 12847212.
van Hagen PM, Hooijkaas H, Vd Beemd MW, Verjans G, Baarsma GS (2003). "T-γδ Receptor Restriction in Peripheral Lymphocytes of Patients with Behçet's Disease". Adamantiades-Behçet's Disease. Advances in Experimental Medicine and Biology. Vol. 528. pp. 267–8. doi:10.1007/0-306-48382-3_53. ISBN 0-306-47757-2. PMID 12918704.
Szczepanski T, van der Velden VH, Hoogeveen PG, de Bie M, Jacobs DC, van Wering ER, van Dongen JJ (May 2004). "Vdelta2-Jalpha rearrangements are frequent in precursor-B-acute lymphoblastic leukemia but rare in normal lymphoid cells". Blood. 103 (10): 3798–804. doi:10.1182/blood-2003-08-2952. PMID 14656882.
De Rosa SC, Andrus JP, Perfetto SP, Mantovani JJ, Herzenberg LA, Herzenberg LA, Roederer M (February 2004). "Ontogeny of gamma delta T cells in humans". Journal of Immunology. 172 (3): 1637–45. doi:10.4049/jimmunol.172.3.1637. PMID 14734745. S2CID 9207247.
Fronková E, Krejcí O, Kalina T, Horváth O, Trka J, Hrusák O (August 2005). "Lymphoid differentiation pathways can be traced by TCR delta rearrangements". Journal of Immunology. 175 (4): 2495–500. doi:10.4049/jimmunol.175.4.2495. PMID 16081821.
Chauhan SK, Tripathy NK, Sinha N, Nityanand S (2006). "T-cell receptor repertoire of circulating gamma delta T-cells in Takayasu's arteritis". Clinical Immunology. 118 (2–3): 243–9. doi:10.1016/j.clim.2005.10.010. PMID 16307908.
Joachims ML, Chain JL, Hooker SW, Knott-Craig CJ, Thompson LF (February 2006). "Human alpha beta and gamma delta thymocyte development: TCR gene rearrangements, intracellular TCR beta expression, and gamma delta developmental potential--differences between men and mice". Journal of Immunology. 176 (3): 1543–52. doi:10.4049/jimmunol.176.3.1543. PMC 1592528. PMID 16424183.
Karrman K, Andersson A, Björgvinsdóttir H, Strömbeck B, Lassen C, Olofsson T, Nguyen-Khac F, Berger R, Bernard O, Fioretos T, Johansson B (July 2006). "Deregulation of cyclin D2 by juxtaposition with T-cell receptor alpha/delta locus in t(12;14)(p13;q11)-positive childhood T-cell acute lymphoblastic leukemia". European Journal of Haematology. 77 (1): 27–34. doi:10.1111/j.0902-4441.2006.t01-1-EJH2553.x. PMID 16548914. S2CID 22205994.
Touvrey C, Borel E, Marche PN, Jouvin-Marche E, Candéias SM (2006). "Gene-specific signal joint modifications during V(D)J recombination of TCRAD locus genes in murine and human thymocytes". Immunobiology. 211 (9): 741–51. doi:10.1016/j.imbio.2006.04.001. PMID 17015149.

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[1] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-2] "Entrez Gene: TRD@ T cell receptor delta locus".

TRD (gene)

References

Further reading