TNFRSF13B

Recettore del fattore di necrosi tissutale 13B
	Struttura del TNFRSF13B
Gene
HUGO	TNFRSF13B CD267; CVID; CVID2; TACI; TNFRSF14B
Entrez	23495
Locus	Chr. 17 p11.2
Proteina
OMIM	604907
UniProt	O14836
	Modifica dati su Wikidata · Manuale

Il recettore del fattore di necrosi tumorale 13B, anche noto come TACI, è una proteina recettoriale che, nell'essere umano, è codificata dal gene TNFRSF13B situato nella regione della sindrome di Smith-Magenis sul cromosoma 17 e fa parte della superfamiglia dei recettori del fattore di necrosi tumorale.

Funzione

Tale recettore controlla la risposta anticorpale indipendente dai linfociti T, l'omeostasi dei linfociti B e il cambiamento degli isotipi. Fu scoperto grazie alla sua capacità di legare CAMLG (calcium signal-modulating cyclophilin ligand), ma il suo ruolo più importante deriva dalla possibilità di legare BAFF e APRIL che, attraverso tale recettore, sono in grado di attivane numerosi fattori di trascrizione che modulano l'attività cellulare, quali NFAT, AP-1 e NF-κB. Interagisce inoltre con TRAF6, TRAF5, TNFSF13 e TRAF2.

Significato clinico

Mutazioni genetiche che conducano a un deficit di funzione di tale recettore possono essere causa di immunodeficienza nell'essere umano e sono un reperto comune nei pazienti affetti da immunodeficienza comune variabile, sindrome caratterizzata da una grave carenza di anticorpi necessari per una congrua risposta immunitaria.

Note

1 2 3 Entrez Gene: TNFRSF13B tumor necrosis factor receptor superfamily, member 13B, su ncbi.nlm.nih.gov.
1 2 3 4 5 X Z Xia, Treanor J, Senaldi G, Khare S D, Boone T, Kelley M, Theill L E, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng S Y, Boyle W J, Hsu H, TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation, in J. Exp. Med., vol. 192, n. 1, UNITED STATES, luglio 2000, pp. 137–43, DOI:10.1084/jem.192.1.137, ISSN 0022-1007 (WC · ACNP), PMC 1887716, PMID 10880535.
↑ G U von Bülow, Bram R J, NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily, in Science, vol. 278, n. 5335, UNITED STATES, ottobre 1997, pp. 138–41, DOI:10.1126/science.278.5335.138, ISSN 0036-8075 (WC · ACNP), PMID 9311921.
1 2 Y Wu, Bressette D, Carrell J A, Kaufman T, Feng P, Taylor K, Gan Y, Cho Y H, Garcia A D, Gollatz E, Dimke D, LaFleur D, Migone T S, Nardelli B, Wei P, Ruben S M, Ullrich S J, Olsen H S, Kanakaraj P, Moore P A, Baker K P, Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS, in J. Biol. Chem., vol. 275, n. 45, UNITED STATES, novembre 2000, pp. 35478–85, DOI:10.1074/jbc.M005224200, ISSN 0021-9258 (WC · ACNP), PMID 10956646.

Bibliografia

Bossen C, Schneider P, BAFF, APRIL and their receptors: structure, function and signaling., in Semin. Immunol., vol. 18, n. 5, 2007, pp. 263–75, DOI:10.1016/j.smim.2006.04.006, PMID 16914324.
Treml LS, Crowley JE, Cancro MP, BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells., in Semin. Immunol., vol. 18, n. 5, 2007, pp. 297–304, DOI:10.1016/j.smim.2006.07.001, PMID 16919470.
Mackay F, Leung H, The role of the BAFF/APRIL system on T cell function., in Semin. Immunol., vol. 18, n. 5, 2007, pp. 284–9, DOI:10.1016/j.smim.2006.04.005, PMID 16931039.
Salzer U, Jennings S, Grimbacher B, To switch or not to switch--the opposing roles of TACI in terminal B cell differentiation., in Eur. J. Immunol., vol. 37, n. 1, 2007, pp. 17–20, DOI:10.1002/eji.200636914, PMID 17171762.
Maruyama K, Sugano S, Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides., in Gene, vol. 138, 1–2, 1994, pp. 171–4, DOI:10.1016/0378-1119(94)90802-8, PMID 8125298.
von Bülow GU, Bram RJ, NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily, in Science, vol. 278, n. 5335, 1997, pp. 138–41, DOI:10.1126/science.278.5335.138, PMID 9311921.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, A Suyama e S Sugano, Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library, in Gene, vol. 200, 1–2, 1997, pp. 149–56, DOI:10.1016/S0378-1119(97)00411-3, PMID 9373149.
Gross JA, Johnston J, Mudri S, Rachel Enselman, Stacey R. Dillon, Karen Madden, Wenfeng Xu, Julia Parrish-Novak e Don Foster, TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease, in Nature, vol. 404, n. 6781, 2000, pp. 995–9, DOI:10.1038/35010115, PMID 10801128.
Xia XZ, Treanor J, Senaldi G, SD Khare, T Boone, M Kelley, LE Theill, A Colombero e I Solovyev, TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation, in J. Exp. Med., vol. 192, n. 1, 2000, pp. 137–43, DOI:10.1084/jem.192.1.137, PMC 1887716, PMID 10880535.
Yan M, Marsters SA, Grewal IS, Scot A. Marsters, Iqbal S. Grewal e Hua Wang, Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity, in Nat. Immunol., vol. 1, n. 1, 2001, pp. 37–41, DOI:10.1038/76889, PMID 10881172.
Marsters SA, Yan M, Pitti RM, Philip E Haas, Vishva M Dixit e Avi Ashkenazi, Interaction of the TNF homologues BLyS and APRIL with the TNF receptor homologues BCMA and TACI, in Curr. Biol., vol. 10, n. 13, 2000, pp. 785–8, DOI:10.1016/S0960-9822(00)00566-2, PMID 10898980.
von Bülow GU, Russell H, Copeland NG, Debra J. Gilbert, Nancy A. Jenkins e Richard J. Bram, Molecular cloning and functional characterization of murine transmembrane activator and CAML interactor (TACI) with chromosomal localization in human and mouse, in Mamm. Genome, vol. 11, n. 8, 2000, pp. 628–32, DOI:10.1007/s003350010125, PMID 10920230.
Wu Y, Bressette D, Carrell JA, T Kaufman, P Feng, K Taylor, Y Gan, YH Cho e AD Garcia, Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS, in J. Biol. Chem., vol. 275, n. 45, 2001, pp. 35478–85, DOI:10.1074/jbc.M005224200, PMID 10956646.
Yu G, Boone T, Delaney J, Nessa Hawkins, Michael Kelley, Meena Ramakrishnan, Susan McCabe, Wan-Rong Qiu e Masayo Kornuc, APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity, in Nat. Immunol., vol. 1, n. 3, 2001, pp. 252–6, DOI:10.1038/79802, PMID 10973284.
Strausberg RL, Feingold EA, Grouse LH, JG Derge, RD Klausner, FS Collins, L Wagner, CM Shenmen e GD Schuler, Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences, in Proc. Natl. Acad. Sci. U.S.A., vol. 99, n. 26, 2003, pp. 16899–903, DOI:10.1073/pnas.242603899, PMC 139241, PMID 12477932.
Novak AJ, Darce JR, Arendt BK, B Harder, K Henderson, W Kindsvogel, JA Gross, PR Greipp e DF Jelinek, Expression of BCMA, TACI, and BAFF-R in multiple myeloma: a mechanism for growth and survival, in Blood, vol. 103, n. 2, 2004, pp. 689–94, DOI:10.1182/blood-2003-06-2043, PMID 14512299.
Ota T, Suzuki Y, Nishikawa T, Tetsuji Otsuki, Tomoyasu Sugiyama, Ryotaro Irie, Ai Wakamatsu, Koji Hayashi e Hiroyuki Sato, Complete sequencing and characterization of 21,243 full-length human cDNAs, in Nat. Genet., vol. 36, n. 1, 2004, pp. 40–5, DOI:10.1038/ng1285, PMID 14702039.
Hymowitz SG, Patel DR, Wallweber HJ, S Runyon, M Yan, J Yin, SK Shriver, NC Gordon e B Pan, Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding, in J. Biol. Chem., vol. 280, n. 8, 2005, pp. 7218–27, DOI:10.1074/jbc.M411714200, PMID 15542592.
Moreaux J, Cremer FW, Reme T, M Raab, K Mahtouk, P Kaukel, V Pantesco, J De Vos e E Jourdan, The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature, in Blood, vol. 106, n. 3, 2005, pp. 1021–30, DOI:10.1182/blood-2004-11-4512, PMC 2408610, PMID 15827134.
Castigli E, Wilson SA, Garibyan L, Rima Rachid, Francisco Bonilla, Lynda Schneider e Raif S Geha, TACI is mutant in common variable immunodeficiency and IgA deficiency, in Nat. Genet., vol. 37, n. 8, 2005, pp. 829–34, DOI:10.1038/ng1601, PMID 16007086.

Voci correlate

Recettore del fattore di necrosi tumorale

Portale Biologia

Portale Medicina

[entrez-1] 1 2 3 Entrez Gene: TNFRSF13B tumor necrosis factor receptor superfamily, member 13B, su ncbi.nlm.nih.gov.

[pmid10880535-2] 1 2 3 4 5 X Z Xia, Treanor J, Senaldi G, Khare S D, Boone T, Kelley M, Theill L E, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng S Y, Boyle W J, Hsu H, TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation, in J. Exp. Med., vol. 192, n. 1, UNITED STATES, luglio 2000, pp. 137–43, DOI:10.1084/jem.192.1.137, ISSN 0022-1007 (WC · ACNP), PMC 1887716, PMID 10880535.

[pmid9311921-3] G U von Bülow, Bram R J, NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily, in Science, vol. 278, n. 5335, UNITED STATES, ottobre 1997, pp. 138–41, DOI:10.1126/science.278.5335.138, ISSN 0036-8075 (WC · ACNP), PMID 9311921.

[pmid10956646-4] 1 2 Y Wu, Bressette D, Carrell J A, Kaufman T, Feng P, Taylor K, Gan Y, Cho Y H, Garcia A D, Gollatz E, Dimke D, LaFleur D, Migone T S, Nardelli B, Wei P, Ruben S M, Ullrich S J, Olsen H S, Kanakaraj P, Moore P A, Baker K P, Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS, in J. Biol. Chem., vol. 275, n. 45, UNITED STATES, novembre 2000, pp. 35478–85, DOI:10.1074/jbc.M005224200, ISSN 0021-9258 (WC · ACNP), PMID 10956646.

V · D · M Antigeni CD
1-100	CD1 · CD2 · CD3 · CD4 · CD5 · CD6 · CD7 · CD8 · CD9 · CD10 · CD11 (a, b, c, d) · CD18 · CD21 · CD27 · CD28 · CD30 · CD32 · CD33 · CD36 · CD38 · CD40 · CD44 · CD50 · CD52 · CD56 · CD62 · CD66 · CD79 (a, b) · CD80 · CD86 · CD95	PDGF-R
101-200	CD120 (a, b) · CD134 · CD137 · CD141 · CD142 · CD143 · CD152 · CD154 · CD155 · CD166 · CD195 · CD197
201-300	CD220 · CD227 · CD234 · CD243 · CD252 · CD261 · CD262 · CD263 · CD264 · CD265 · CD266 · CD267 · CD268 · CD269 · CD270 · CD292
301-400	CD340 · CD357 · CD358

Recettore del fattore di necrosi tissutale 13B
Struttura del TNFRSF13B
Gene
HUGO	TNFRSF13B CD267; CVID; CVID2; TACI; TNFRSF14B
Entrez	23495
Locus	Chr. 17 p11.2
Proteina
OMIM	604907
UniProt	O14836
Modifica dati su Wikidata · Manuale