CD137

Recettore del fattore di necrosi tissutale 9
Gene
HUGO	TNFRSF14 4-1BB; CD137; CDw137; ILA
Entrez	3604
Locus	Chr. 1 p36.23
Proteina
OMIM	602250
UniProt	Q07011
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CD137, noto anche come recettore del fattore di necrosi tumorale 9, 4-1BB e ILA (dall'acronimo in lingua inglese induced by lymphocyte activation) è una proteina recettoriale che, nell'essere umano, è codificata dal gene TNFRSF9 e fa parte della superfamiglia dei recettori del fattore di necrosi tumorale.

Espressione e funzione

Si trova espresso nei linfociti T attivati, in particolar modo quelli citotossici (CD8⁺), nelle cellule dendritiche, nelle cellule NK, nei granulociti e nelle cellule endoteliali situate in siti di infiammazione. Agisce incentivando la proliferazione e la sopravvivenza dei linfociti T, l'attività citolitica e la produzione di interleuchina 2; inoltre, nei topi, ha dimostrato un'attività di potenziamento della risposta immunitaria contro le cellule tumorali. Agisce legando TRAF2.

Note

↑ Kwon BS, Weissman SM, cDNA sequences of two inducible T-cell genes, in Proc. Natl. Acad. Sci. U.S.A., vol. 86, n. 6, 1989, pp. 1963–7, DOI:10.1073/pnas.86.6.1963, PMC 286825, PMID 2784565.
↑ Schwarz H, Tuckwell J, Lotz M, A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family, in Gene, vol. 134, n. 2, 1993, pp. 295–8, DOI:10.1016/0378-1119(93)90110-O, PMID 8262389.
↑ Schwarz H, Blanco FJ, von Kempis J, J Valbracht e M Lotz, ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival, in Blood, vol. 87, n. 7, 1996, pp. 2839–45, PMID 8639902.
↑ Sica G, Chen L, Biochemical and immunological characteristics of 4-1BB (CD137) receptor and ligand and potential applications in cancer therapy, in Arch. Immunol. Ther. Exp. (Warsz.), vol. 47, n. 5, 2000, pp. 275–9, PMID 10604232.
↑ I K Jang, Lee Z H, Kim Y J, Kim S H, Kwon B S, Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B, in Biochem. Biophys. Res. Commun., vol. 242, n. 3, UNITED STATES, Jan. 1998, pp. 613–20, DOI:10.1006/bbrc.1997.8016, ISSN 0006-291X (WC · ACNP), PMID 9464265.
↑ R H Arch, Thompson C B, 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB, in Mol. Cell. Biol., vol. 18, n. 1, UNITED STATES, Jan. 1998, pp. 558–65, ISSN 0270-7306 (WC · ACNP), PMC 121523, PMID 9418902.

Bibliografia

Schwarz H, Biological activities of reverse signal transduction through CD137 ligand, in J. Leukoc. Biol., vol. 77, n. 3, 2005, pp. 281–6, DOI:10.1189/jlb.0904558, PMID 15618293.
Kwon BS, Weissman SM, cDNA sequences of two inducible T-cell genes, in Proc. Natl. Acad. Sci. U.S.A., vol. 86, n. 6, 1989, pp. 1963–7, DOI:10.1073/pnas.86.6.1963, PMC 286825, PMID 2784565.
Zhou Z, Kim S, Hurtado J, ZH Lee, KK Kim, KE Pollok e BS Kwon, Characterization of human homologue of 4-1BB and its ligand, in Immunol. Lett., vol. 45, 1–2, 1995, pp. 67–73, DOI:10.1016/0165-2478(94)00227-I, PMID 7622190.
Alderson MR, Smith CA, Tough TW, Terri Davis-Smith, Richard J. Armitage, Ben Falk, Eileen Roux, Elizabeth Baker e Grant R. Sutherland, Molecular and biological characterization of human 4-1BB and its ligand, in Eur. J. Immunol., vol. 24, n. 9, 1994, pp. 2219–27, DOI:10.1002/eji.1830240943, PMID 8088337.
Schwarz H, Tuckwell J, Lotz M, A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family, in Gene, vol. 134, n. 2, 1994, pp. 295–8, DOI:10.1016/0378-1119(93)90110-O, PMID 8262389.
Loo DT, Chalupny NJ, Bajorath J, WW Shuford, RS Mittler e A Aruffo, Analysis of 4-1BBL and laminin binding to murine 4-1BB, a member of the tumor necrosis factor receptor superfamily, and comparison with human 4-1BB, in J. Biol. Chem., vol. 272, n. 10, 1997, pp. 6448–56, DOI:10.1074/jbc.272.10.6448, PMID 9045669.
Schwarz H, Arden K, Lotz M, CD137, a member of the tumor necrosis factor receptor family, is located on chromosome 1p36, in a cluster of related genes, and colocalizes with several malignancies, in Biochem. Biophys. Res. Commun., vol. 235, n. 3, 1997, pp. 699–703, DOI:10.1006/bbrc.1997.6870, PMID 9207223.
Arch RH, Thompson CB, 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB, in Mol. Cell. Biol., vol. 18, n. 1, 1998, pp. 558–65, PMC 121523, PMID 9418902.
Jang IK, Lee ZH, Kim YJ, Seung H. Kim e Byoung S. Kwon, Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B, in Biochem. Biophys. Res. Commun., vol. 242, n. 3, 1998, pp. 613–20, DOI:10.1006/bbrc.1997.8016, PMID 9464265.
Kim YJ, Kim SH, Mantel P, Kwon BS, Human 4-1BB regulates CD28 co-stimulation to promote Th1 cell responses, in Eur. J. Immunol., vol. 28, n. 3, 1998, pp. 881–90, DOI:10.1002/(SICI)1521-4141(199803)28:03<881::AID-IMMU881>3.0.CO;2-0, PMID 9541583.
Saoulli K, Lee SY, Cannons JL, WC Yeh, A Santana, MD Goldstein, N Bangia, MA Debenedette e TW Mak, CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand, in J. Exp. Med., vol. 187, n. 11, 1998, pp. 1849–62, DOI:10.1084/jem.187.11.1849, PMC 2212301, PMID 9607925.
Langstein J, Michel J, Schwarz H, CD137 induces proliferation and endomitosis in monocytes, in Blood, vol. 94, n. 9, 1999, pp. 3161–8, PMID 10556203.
Jang LK, Lee ZH, Kim HH, JM Hill, JD Kim e BS Kwon, A novel leucine-rich repeat protein (LRR-1): potential involvement in 4-1BB-mediated signal transduction, in Mol. Cells, vol. 12, n. 3, 2002, pp. 304–12, PMID 11804328.
Cooper D, Bansal-Pakala P, Croft M, 4-1BB (CD137) controls the clonal expansion and survival of CD8 T cells in vivo but does not contribute to the development of cytotoxicity, in Eur. J. Immunol., vol. 32, n. 2, 2002, pp. 521–9, DOI:10.1002/1521-4141(200202)32:2<521::AID-IMMU521>3.0.CO;2-X, PMID 11828369.
Wilcox RA, Chapoval AI, Gorski KS, M Otsuji, T Shin, DB Flies, K Tamada, RS Mittler e H Tsuchiya, Cutting edge: Expression of functional CD137 receptor by dendritic cells, in J. Immunol., vol. 168, n. 9, 2002, pp. 4262–7, PMID 11970964.
Shulzhenko N, Morgun A, Chinellato AP, GF Rampim, RV Diniz, DR Almeida e M Gerbase-Delima, CD27 but not CD70 and 4-1BB intragraft gene expression is a risk factor for acute cardiac allograft rejection in humans, in Transplant. Proc., vol. 34, n. 2, 2002, pp. 474–5, DOI:10.1016/S0041-1345(02)02600-3, PMID 12009595.
Pauly S, Broll K, Wittmann M, G Giegerich e H Schwarz, CD137 is expressed by follicular dendritic cells and costimulates B lymphocyte activation in germinal centers, in J. Leukoc. Biol., vol. 72, n. 1, 2002, pp. 35–42, PMID 12101260.

Voci correlate

Portale Biologia

Portale Medicina

[1] Kwon BS, Weissman SM, cDNA sequences of two inducible T-cell genes, in Proc. Natl. Acad. Sci. U.S.A., vol. 86, n. 6, 1989, pp. 1963–7, DOI:10.1073/pnas.86.6.1963, PMC 286825, PMID 2784565.

[2] Schwarz H, Tuckwell J, Lotz M, A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family, in Gene, vol. 134, n. 2, 1993, pp. 295–8, DOI:10.1016/0378-1119(93)90110-O, PMID 8262389.

[3] Schwarz H, Blanco FJ, von Kempis J, J Valbracht e M Lotz, ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival, in Blood, vol. 87, n. 7, 1996, pp. 2839–45, PMID 8639902.

[4] Sica G, Chen L, Biochemical and immunological characteristics of 4-1BB (CD137) receptor and ligand and potential applications in cancer therapy, in Arch. Immunol. Ther. Exp. (Warsz.), vol. 47, n. 5, 2000, pp. 275–9, PMID 10604232.

[pmid9464265-5] I K Jang, Lee Z H, Kim Y J, Kim S H, Kwon B S, Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B, in Biochem. Biophys. Res. Commun., vol. 242, n. 3, UNITED STATES, Jan. 1998, pp. 613–20, DOI:10.1006/bbrc.1997.8016, ISSN 0006-291X (WC · ACNP), PMID 9464265.

[pmid9418902-6] R H Arch, Thompson C B, 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB, in Mol. Cell. Biol., vol. 18, n. 1, UNITED STATES, Jan. 1998, pp. 558–65, ISSN 0270-7306 (WC · ACNP), PMC 121523, PMID 9418902.

V · D · M Antigeni CD
1-100	CD1 · CD2 · CD3 · CD4 · CD5 · CD6 · CD7 · CD8 · CD9 · CD10 · CD11 (a, b, c, d) · CD18 · CD21 · CD27 · CD28 · CD30 · CD32 · CD33 · CD36 · CD38 · CD40 · CD44 · CD50 · CD52 · CD56 · CD62 · CD66 · CD79 (a, b) · CD80 · CD86 · CD95	PDGF-R
101-200	CD120 (a, b) · CD134 · CD137 · CD141 · CD142 · CD143 · CD152 · CD154 · CD155 · CD166 · CD195 · CD197
201-300	CD220 · CD227 · CD234 · CD243 · CD252 · CD261 · CD262 · CD263 · CD264 · CD265 · CD266 · CD267 · CD268 · CD269 · CD270 · CD292
301-400	CD340 · CD357 · CD358

Recettore del fattore di necrosi tissutale 9
Gene
HUGO	TNFRSF14 4-1BB; CD137; CDw137; ILA
Entrez	3604
Locus	Chr. 1 p36.23
Proteina
OMIM	602250
UniProt	Q07011
Modifica dati su Wikidata · Manuale