B3GAT3

B3GAT3
Uygun yapılar
PDB	Ortolog araması: PDBe RCSB
PDB kimlik kodlarının listesi
	1FGG, 1KWS, 3CU0
Tanımlayıcılar
Başka adlar	B3GAT3
Dış kimlikler	OMIM: 606374 MGI: 1919977 HomoloGene: 56554 GeneCards: B3GAT3
Enzim Komisyon numarası	2.4.1.135
Gen yerleşimi (İnsan)
Krom.	11. Kromozom (insan)
Bitiş	62,622,154 bç
RNA ekspresyonu deseni
	; ;
	Daha çok ekspresyon verisi başvurusu
Gen ontolojisi
Moleküler işlevi	• transferase activity; • protein phosphatase activator activity; • glucuronosyltransferase activity; • metal ion binding; • GO:0001948, GO:0016582 protein bağlanması; • galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity;
Hücresel bileşeni	• integral component of membrane; • Golgi aygıtı; • membrane; • cis-Golgi network; • extracellular exosome; • Golgi membrane;
Biyolojik süreci	• positive regulation of intracellular protein transport; • glycosaminoglycan metabolic process; • heparan sulfate proteoglycan biosynthetic process; • GO:0048554 positive regulation of catalytic activity; • GO:0033578, GO:0033577, GO:0033575, GO:0033576 protein glycosylation; • glycosaminoglycan biosynthetic process; • chondroitin sulfate proteoglycan biosynthetic process; • dermatan sulfate proteoglycan biosynthetic process; • chondroitin sulfate metabolic process; • carbohydrate metabolic process; • regulation of phosphoprotein phosphatase activity;
	Kaynaklar:Amigo / QuickGO
Ortologlar
	26229
	72727
	ENSG00000149541
	ENSMUSG00000071649
	O94766
	P58158
	NM_001288721; NM_001288722; NM_001288723; NM_012200
	NM_024256
	NP_001275650; NP_001275651; NP_001275652; NP_036332
	NP_077218
	Vikiveri
İnsan'ı Gör/Düzenle	Fare'yi Gör/Düzenle

Galaktozilgalaktozilksilozilprotein 3-beta-glukuronoziltransferaz 3, insanlarda B3GAT3 geni tarafından kodlanan bir enzimdir.

Protein, glukuroniltransferaz gen ailesinin üyesi olan bu gen tarafından kodlanmıştır; sıkı alıcı özgüllüğü sergileyen enzimler, indirgenmeyen terminal şekerleri ve bunların anomerik bağlantılarını tanır. Bu gen ürünü, proteoglikanların bağlantı bölgesinin biyosentezinin son aşamasında bir glukuronil transfer reaksiyonu yoluyla glikozaminoglikan-protein bağlantısının oluşumunu katalizler.

Kaynakça

1 2 3 GRCh38: Ensembl release 89: ENSG00000149541 - Ensembl, May 2017
↑ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans". J Biol Chem. 273 (12). Apr 1998. ss. 6615-8.
1 2 "Entrez Gene: B3GAT3 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)". 5 Aralık 2010 tarihinde kaynağından arşivlendi.

Dış bağlantılar

Human B3GAT330 Aralık 2019 tarihinde Wayback Machine sitesinde arşivlendi. genome location and B3GAT3 gene details page in the UCSC Genome Browser [en].
Overview of all the structural information available in the PDB for UniProt: O947667 Temmuz 2019 tarihinde Wayback Machine sitesinde arşivlendi. (Human Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (B3GAT3)) at the PDBe-KB [en].

Konuyla ilgili yayınlar

"Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). 2005. ss. 1173-8.
"Stimulation of proteoglycan synthesis by glucuronosyltransferase-I gene delivery: A strategy to promote cartilage repair". Proc. Natl. Acad. Sci. U.S.A. 101 (52). 2005. ss. 18087-92.
"Phosphorylation and sulfation of oligosaccharide substrates critically influence the activity of human beta1,4-galactosyltransferase 7 (GalT-I) and beta1,3-glucuronosyltransferase I (GlcAT-I) involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans". J. Biol. Chem. 280 (2). 2005. ss. 1417-25.
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B). 2004. ss. 2121-7.
"The functional glycosyltransferase signature sequence of the human beta 1,3-glucuronosyltransferase is a XDD motif". J. Biol. Chem. 278 (34). 2003. ss. 32219-26.
"Generation and initial analysis of more than 15.000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26). 2003. ss. 16899-903.
"Human glycosaminoglycan glucuronyltransferase I gene and a related processed pseudogene: genomic structure, chromosomal mapping and characterization". Biochem. J. 358 (Pt 3). 2001. ss. 539-46.
"Heparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase I". J. Biol. Chem. 275 (44). 2000. ss. 34580-5.
"Structure/function of the human Ga1beta1,3-glucuronosyltransferase. Dimerization and functional activity are mediated by two crucial cysteine residues". J. Biol. Chem. 275 (36). 2000. ss. 28254-60.
"Characterization of recombinant human glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans". FEBS Lett. 459 (3). 1999. ss. 415-20.
"Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway". Proc. Natl. Acad. Sci. U.S.A. 96 (3). 1999. ss. 974-9.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000149541 - Ensembl, May 2017

[2] "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9506957-4] "Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans". J Biol Chem. 273 (12). Apr 1998. ss. 6615-8.

[entrez-5] 1 2 "Entrez Gene: B3GAT3 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)". 5 Aralık 2010 tarihinde kaynağından arşivlendi.