Dotarizin

Dotarizin, migren tedavisinde kullanılan bir ilaç, kalsiyum kanal blokörüdür. 5HT2A reseptöründe ve daha az oranda 5HT1A ile 5HT2C reseptörlerinde antagonist olarak görev yapar.

Kaynakça

  1. ↑ "Mechanisms of blockade by the novel migraine prophylactic agent, dotarizine, of various brain and peripheral vessel contractility". European Journal of Pharmacology. 411 (3): 289-99. Ocak 2001. doi:10.1016/S0014-2999(00)00897-9. PMID 11164387.
  2. ↑ "Antimigraine dotarizine blocks P/Q Ca2+ channels and exocytosis in a voltage-dependent manner in chromaffin cells". European Journal of Pharmacology. 481 (1): 41-50. Kasım 2003. doi:10.1016/j.ejphar.2003.09.013. PMID 14637173.
  3. ↑ "Clinical pharmacokinetics and tolerability of dotarizine in healthy subjects after single and multiple oral administration". Methods and Findings in Experimental and Clinical Pharmacology. 19 (5): 343-50. Haziran 1997. PMID 9379783.
  4. ↑ "Serotonergic effects of dotarizine in coronary artery and in oocytes expressing 5-HT2 receptors". European Journal of Pharmacology. 332 (2): 183-93. Ağustos 1997. doi:10.1016/S0014-2999(97)01073-X. PMID 9286620.