GABRG3

GABRG3
Identifiers
Aliases	GABRG3, gamma-aminobutyric acid type A receptor gamma3 subunit, gamma-aminobutyric acid type A receptor subunit gamma3
External IDs	OMIM: 600233; MGI: 95624; GeneCards: GABRG3
Gene location (Human)
Chr.	Chromosome 15 (human)
End	27,541,984 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	57,036,936 bp
RNA expression pattern
	Top expressed in
	testicle; ; right testis; ; left testis; ; prefrontal cortex; ; gonad; ; anterior pituitary; ; sperm; ; Brodmann area 9; ; hypothalamus; ; cingulate gyrus;
	Top expressed in
	epithelium of lens; ; lumbar subsegment of spinal cord; ; nucleus accumbens; ; superior frontal gyrus; ; lateral septal nucleus; ; dorsal striatum; ; prefrontal cortex; ; dentate gyrus of hippocampal formation granule cell; ; lumbar spinal ganglion; ; primary visual cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	chloride channel activity; extracellular ligand-gated ion channel activity; GABA-A receptor activity; ion channel activity; transmembrane signaling receptor activity; inhibitory extracellular ligand-gated ion channel activity; benzodiazepine receptor activity; GABA-gated chloride ion channel activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; cell junction; plasma membrane; postsynaptic membrane; synapse; membrane; chloride channel complex; GABA-ergic synapse; integral component of synaptic membrane; integral component of plasma membrane; dendrite membrane; neuron projection; postsynapse; GABA-A receptor complex;
Biological process	gamma-aminobutyric acid signaling pathway; chloride transport; chloride transmembrane transport; ion transport; ion transmembrane transport; signal transduction; chemical synaptic transmission; regulation of membrane potential; nervous system process; synaptic transmission, GABAergic; regulation of postsynaptic membrane potential;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	2567
	14407
	ENSG00000182256
	ENSMUSG00000055026
	Q99928
	P27681
	NM_001270873; NM_033223
	NM_008074; NM_177273
	NP_001257802; NP_150092
	NP_032100
	Wikidata
View/Edit Human	View/Edit Mouse

GABA_A receptor-γ3, also known as GABRG3, is a protein which in humans is encoded by the GABRG3 gene.

Function

GABRG3 is a subunit of the GABA_A receptor for the neurotransmitter gamma-Aminobutyric acid (GABA).

Association with alcoholism

Genetic markers near the GABRG3 gene are statistically linked to alcoholism.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000182256 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055026 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3".
↑ Dick DM, Edenberg HJ, Xuei X, Goate A, Kuperman S, Schuckit M, Crowe R, Smith TL, Porjesz B, Begleiter H, Foroud T (January 2004). "Association of GABRG3 with alcohol dependence". Alcohol. Clin. Exp. Res. 28 (1): 4–9. doi:10.1097/01.ALC.0000108645.54345.98. PMID 14745296.

External links

GABRG3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000182256 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000055026 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GABRG3 gamma-aminobutyric acid (GABA) A receptor, gamma 3".

[pmid14745296-6] Dick DM, Edenberg HJ, Xuei X, Goate A, Kuperman S, Schuckit M, Crowe R, Smith TL, Porjesz B, Begleiter H, Foroud T (January 2004). "Association of GABRG3 with alcohol dependence". Alcohol. Clin. Exp. Res. 28 (1): 4–9. doi:10.1097/01.ALC.0000108645.54345.98. PMID 14745296.

GABRG3

Function

Association with alcoholism

See also

References

Further reading

External links