P2RX2

P2RX2
Identifiers
Aliases	P2RX2, DFNA41, P2X2, purinergic receptor P2X 2
External IDs	OMIM: 600844; MGI: 2665170; GeneCards: P2RX2
Gene location (Human)
Chr.	Chromosome 12 (human)
End	132,622,388 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	110,491,078 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; right lung; ; right uterine tube; ; prostate; ; caput epididymis; ; tail of epididymis; ; corpus epididymis; ; hippocampus proper; ; spleen; ; upper lobe of left lung;
	Top expressed in
	vestibular membrane of cochlear duct; ; otolith organ; ; utricle; ; seminiferous tubule; ; spermatocyte; ; ganglion of vagus nerve; ; spermatid; ; vestibular sensory epithelium; ; cochlea; ; embryo;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	purinergic nucleotide receptor activity; extracellularly ATP-gated cation channel activity; ion channel activity; ligand-gated ion channel activity; identical protein binding; ATP binding; ATP-gated ion channel activity;
Cellular component	integral component of membrane; membrane; receptor complex; integral component of nuclear inner membrane; integral component of plasma membrane; intracellular anatomical structure; apical plasma membrane; plasma membrane; postsynapse; soma;
Biological process	peristalsis; response to ATP; positive regulation of calcium-mediated signaling; response to hypoxia; positive regulation of calcium ion transport into cytosol; urinary bladder smooth muscle contraction; hearing; ion transport; response to organic substance; cation transmembrane transport; neuromuscular synaptic transmission; behavioral response to pain; neuromuscular junction development; skeletal muscle fiber development; detection of hypoxic conditions in blood by carotid body chemoreceptor signaling; protein homooligomerization; response to carbohydrate; sensory perception of taste; chemical synaptic transmission; blood coagulation; purinergic nucleotide receptor signaling pathway; excitatory postsynaptic potential; response to ischemia; cation transport; ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	22953
	231602
	ENSG00000187848
	ENSMUSG00000029503
	Q9UBL9
	Q8K3P1
NM_001282164; NM_001282165; NM_012226; NM_016318; NM_170682;
	NM_170683; NM_174872; NM_174873
	NM_001164833; NM_001164834; NM_153400; NM_001310700; NM_001310701
NP_001269093; NP_001269094; NP_036358; NP_057402; NP_733782;
	NP_733783; NP_777361; NP_777362
	NP_001158305; NP_001158306; NP_001297629; NP_001297630; NP_700449
	Wikidata
View/Edit Human	View/Edit Mouse

P2X purinoceptor 2 is a protein that in humans is encoded by the P2RX2 gene.

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a cation conducting ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for this gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000187848 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029503 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, van Biesen T, Kowaluk EA, Jarvis MF (Dec 1999). "Molecular and functional characterization of human P2X(2) receptors". Mol Pharmacol. 56 (6): 1171–81. doi:10.1124/mol.56.6.1171. PMID 10570044.
↑ Brake AJ, Wagenbach MJ, Julius D (Oct 1994). "New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor". Nature. 371 (6497): 519–23. Bibcode:1994Natur.371..519B. doi:10.1038/371519a0. PMID 7523952. S2CID 4371044.
1 2 "Entrez Gene: P2RX2 purinergic receptor P2X, ligand-gated ion channel, 2".

External links

P2RX2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000187848 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029503 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10570044-5] Lynch KJ, Touma E, Niforatos W, Kage KL, Burgard EC, van Biesen T, Kowaluk EA, Jarvis MF (Dec 1999). "Molecular and functional characterization of human P2X(2) receptors". Mol Pharmacol. 56 (6): 1171–81. doi:10.1124/mol.56.6.1171. PMID 10570044.

[pmid7523952-6] Brake AJ, Wagenbach MJ, Julius D (Oct 1994). "New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor". Nature. 371 (6497): 519–23. Bibcode:1994Natur.371..519B. doi:10.1038/371519a0. PMID 7523952. S2CID 4371044.

[entrez-7] 1 2 "Entrez Gene: P2RX2 purinergic receptor P2X, ligand-gated ion channel, 2".

P2RX2

References

Further reading

External links