POLR2M

POLR2M
Identifiers
Aliases	POLR2M, GCOM1, GRINL1A, Gdown, Gdown1, polymerase (RNA) II subunit M, RNA polymerase II subunit M
External IDs	OMIM: 606485; MGI: 107282; GeneCards: POLR2M
Gene location (Human)
Chr.	Chromosome 15 (human)
End	57,782,762 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	71,393,217 bp
RNA expression pattern
	Top expressed in
	germinal epithelium; ; muscle of thigh; ; Achilles tendon; ; tail of epididymis; ; Skeletal muscle tissue of rectus abdominis; ; secondary oocyte; ; Epithelium of choroid plexus; ; vena cava; ; optic nerve; ; biceps brachii;
	Top expressed in
	somite; ; mandibular prominence; ; hand; ; tail of embryo; ; genital tubercle; ; maxillary prominence; ; muscle of thigh; ; foot; ; abdominal wall; ; choroid plexus of fourth ventricle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-directed 5'-3' RNA polymerase activity; protein binding;
Cellular component	RNA polymerase II, holoenzyme; soma; nuclear envelope; nucleus; cytoplasm; cell junction; plasma membrane; Z discdkac; cytoskeleton; membrane; I band; cortical actin cytoskeleton; extrinsic component of cytoplasmic side of plasma membrane; intracellular anatomical structure;
Biological process	maintenance of ER location; RNA biosynthetic process; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	81488
	28015
	ENSG00000255529
	ENSMUSG00000032199
	P0CAP2; Q6EEV4; P0CAP1
	Q6P6I6
	NM_001018102; NM_015532
	NM_001164793; NM_178602
NP_001018112; NP_056347; NP_001018112.1; NP_056347.1; NP_001018110;
	NP_689664
	NP_001158265; NP_848717
	Wikidata
View/Edit Human	View/Edit Mouse

DNA-directed RNA polymerase II subunit GRINL1A is a protein that in humans is encoded by the POLR2M gene (previously GRINL1A). This protein is a component of Pol II(G), a variant form of the RNA polymerase II complex.

This gene (GRINL1A) is part of a complex transcript unit that includes the gene for GRINL1A combined protein (Gcom1). Transcription of this gene occurs at a downstream promoter, with at least three different alternatively spliced variants, grouped together as Gdown for GRINL1A downstream transcripts. The Gcom1 gene uses an upstream promoter for transcription and also has multiple alternatively spliced variants.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000255529 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032199 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 "Entrez Gene: GRINL1A glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A".

External links

GRINL1A+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000255529 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032199 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 3 "Entrez Gene: GRINL1A glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A".

POLR2M

See also

References

Further reading

External links