DNA polymerase III, delta subunit

DNA polymerase III, delta subunit
DNA polymerase III, delta subunit
	atpgs bound e. coli clamp loader complex
Identifiers
Symbol	DNA_pol3_delta
Pfam	PF06144
Pfam clan	CL0023
InterPro	IPR010372
SCOP2	1jql / SCOPe / SUPFAM
PDB
Available protein structures:
PDB	IPR010372 PF06144 (ECOD; PDBsum)
AlphaFold	IPR010372; PF06144;

Search for
Structures	Swiss-model
Domains	InterPro

DNA polymerase III, delta subunit
DNA polymerase III, delta subunit
Identifiers
Organism	Escherichia coli; (str. K-12 substr. MG1655)
Symbol	holA
Entrez	947573
Orthologs	NCBI: entry; OMA: entry
RefSeq (Prot)	NP_415173.1
UniProt	P28630
Other data
EC number	2.7.7.7
Chromosome	genome: 0.67 - 0.67 Mb
Structures
Search for
Structures	Swiss-model
Domains	InterPro

In molecular biology, the δ (delta) subunit of DNA polymerase III is encoded by the holA gene in E. coli and other bacteria. Along with the γ, δ', χ, and ψ subunits that make up the core polymerase, and the β accessory proteins, the δ subunit is responsible for the high speed and processivity of polIII.

References

↑ Dong Z, Onrust R, Skangalis M, O'Donnell M (June 1993). "DNA polymerase III accessory proteins. I. holA and holB encoding delta and delta'" (PDF). The Journal of Biological Chemistry. 268 (16): 11758–65. doi:10.1016/S0021-9258(19)50264-2. PMID 8505303.
↑ Carter JR, Franden MA, Aebersold R, McHenry CS (1992). "Molecular cloning, sequencing, and overexpression of the structural gene encoding the delta subunit of Escherichia coli DNA polymerase III holoenzyme". Journal of Bacteriology. 174 (21): 7013–25. doi:10.1128/jb.174.21.7013-7025.1992. PMC 207382. PMID 1400251.

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[1] Dong Z, Onrust R, Skangalis M, O'Donnell M (June 1993). "DNA polymerase III accessory proteins. I. holA and holB encoding delta and delta'" (PDF). The Journal of Biological Chemistry. 268 (16): 11758–65. doi:10.1016/S0021-9258(19)50264-2. PMID 8505303.

[pmid1400251-2] Carter JR, Franden MA, Aebersold R, McHenry CS (1992). "Molecular cloning, sequencing, and overexpression of the structural gene encoding the delta subunit of Escherichia coli DNA polymerase III holoenzyme". Journal of Bacteriology. 174 (21): 7013–25. doi:10.1128/jb.174.21.7013-7025.1992. PMC 207382. PMID 1400251.