SSBP2

SSBP2

Identifiers

SSBP2, HSPC116, SOSS-B2, single stranded DNA binding protein 2

External IDs

OMIM: 607389; MGI: 1914220; GeneCards: SSBP2

Gene location (Human)

Chr.	Chromosome 5 (human)

Band	5q14.1	Start	81,412,804 bp
Band	5q14.1	End	81,751,797 bp

Gene location (Mouse)

Chr.	Chromosome 13 (mouse)

Band	13\|13 C3	Start	91,460,283 bp
Band	13\|13 C3	End	91,703,429 bp

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

ventricular zone

ganglionic eminence

Achilles tendon

popliteal artery

tibial arteries

gastric mucosa

Descending thoracic aorta

right coronary artery

canal of the cervix

left ovary

Top expressed in

facial motor nucleus

olfactory epithelium

ciliary body

medial ganglionic eminence

thymus

epithelium of lens

vestibular sensory epithelium

Rostral migratory stream

vas deferens

barrel cortex

More reference expression data


More reference expression data

Gene ontology
Molecular function	single-stranded DNA binding DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding
Cellular component	cytoplasm nucleus
Biological process	regulation of transcription, DNA-templated transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO

Databases

NCBI: entry; OMA: entry

Species

Human

Mouse


23635


66970


ENSG00000145687


ENSMUSG00000003992


P81877


Q9CYZ8

RefSeq (mRNA)

NM_001256732 NM_001256733 NM_001256734 NM_001256735 NM_001256736
NM_012446 NM_001345886 NM_001394350 NM_001394351 NM_001394352


NM_024186 NM_024272 NM_001360775 NM_001360776

RefSeq (protein)

NP_001243661 NP_001243662 NP_001243663 NP_001243664 NP_001243665
NP_001332815 NP_036578


NP_077148 NP_077234 NP_001347704 NP_001347705

Location (UCSC)

Chr 5: 81.41 – 81.75 Mb

Chr 13: 91.46 – 91.7 Mb

PubMed search

View/Edit Human

View/Edit Mouse

Single-stranded DNA-binding protein 2 is a protein that in humans is encoded by the SSBP2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000145687 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000003992 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
↑ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
↑ "Entrez Gene: SSBP2 single-stranded DNA binding protein 2".

Further reading

Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Castro P, Liang H, Liang JC, Nagarajan L (2003). "A novel, evolutionarily conserved gene family with putative sequence-specific single-stranded DNA-binding activity". Genomics. 80 (1): 78–85. doi:10.1006/geno.2002.6805. PMID 12079286.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Liang H, Samanta S, Nagarajan L (2005). "SSBP2, a candidate tumor suppressor gene, induces growth arrest and differentiation of myeloid leukemia cells". Oncogene. 24 (16): 2625–34. doi:10.1038/sj.onc.1208167. PMID 15782145.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Fleisig HB, Orazio NI, Liang H, et al. (2007). "Adenoviral E1B55K oncoprotein sequesters candidate leukemia suppressor sequence-specific single-stranded DNA-binding protein 2 into aggresomes". Oncogene. 26 (33): 4797–805. doi:10.1038/sj.onc.1210281. PMID 17311003.

DNA replication (comparing prokaryotic to eukaryotic)

Prokaryotic (initiation)	Pre-replication complex dnaC Helicase dnaA dnaB T7 Primase dnaG
Eukaryotic (preparation in G1 phase)	Pre-replication complex Origin recognition complex ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 Cdc6 Cdt1 Minichromosome maintenance MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 Licensing factor Autonomously replicating sequence Single-strand binding protein SSBP2 SSBP3 SSBP4 RNase H RNASEH1 RNASEH2A Helicase: HFM1 Primase: PRIM1 PRIM2
Both	Origin of replication/Ori/Replicon Replication fork Lagging and leading strands Okazaki fragments Primer

Prokaryotic (elongation)	DNA polymerase III holoenzyme dnaC dnaE dnaH dnaN dnaQ dnaT dnaX holA holB holC holD holE Replisome DNA ligase DNA clamp Topoisomerase DNA gyrase Prokaryotic DNA polymerase: DNA polymerase I Klenow fragment
Eukaryotic (synthesis in S phase)	Replication factor C RFC1 Flap endonuclease FEN1 Topoisomerase Replication protein A RPA1 Eukaryotic DNA polymerase: alpha POLA1 POLA2 PRIM1 PRIM2 delta POLD1 POLD2 POLD3 POLD4 epsilon POLE POLE2 POLE3 POLE4 DNA clamp PCNA Control of chromosome duplication
Both	Movement: Processivity DNA ligase

Telomere: Telomerase
- TERT
- TERC
- DKC1

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by adding missing information.